Western Blot (WB)
(GRM6 Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the GRM6 antibody detected the GRM6 protein (arrow).)
Rabbit anti-Human GRM6 Polyclonal Antibody | anti-GRM6 antibody
GRM6 Antibody (Center)
Western Blot (WB)
(GRM6 Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the GRM6 antibody detected the GRM6 protein (arrow).)
Western Blot (WB)
(GRM6 Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the GRM6 antibody detected the GRM6 protein (arrow).)
the central nervous system and activates both ionotropic and
metabotropic glutamate receptors. Glutamatergic neurotransmission
is involved in most aspects of normal brain function and can be
perturbed in many neuropathologic conditions. The metabotropic
glutamate receptors are a family of G protein-coupled receptors,
that have been divided into 3 groups on the basis of sequence
homology, putative signal transduction mechanisms, and
pharmacologic properties. Group I includes GRM1 and GRM5 and these
receptors have been shown to activate phospholipase C. Group II
includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
and GRM8. Group II and III receptors are linked to the inhibition
of the cyclic AMP cascade but differ in their agonist
selectivities.
Fonseca, F., et al. Mol Diagn Ther 14(3):171-178(2010)
Beqollari, D., et al. Mol. Pharmacol. 76(5):992-997(2009)
Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)
Xu, X., et al. Mol. Vis. 15, 2094-2100 (2009) :
NCBI and Uniprot Product Information
NCBI Description
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]
Uniprot Description
mGluR6: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B). This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background. Belongs to the G-protein coupled receptor 3 family.
Protein type: Receptor, GPCR; GPCR, family 3; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q35
Cellular Component: presynaptic membrane; Golgi membrane; endoplasmic reticulum membrane; integral to plasma membrane; dendrite; plasma membrane
Molecular Function: G-protein coupled receptor activity; protein binding; group III metabotropic glutamate receptor activity; protein homodimerization activity; glutamate receptor activity
Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; retina development in camera-type eye; metabotropic glutamate receptor signaling pathway; detection of light stimulus involved in visual perception; locomotory behavior; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway; detection of visible light
Disease: Night Blindness, Congenital Stationary, Type 1b
Research Articles on GRM6
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Product Notes
The GRM6 grm6 (Catalog #AAA9201183) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 369-398. The GRM6 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GRM6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the GRM6 grm6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRM6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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