Rabbit GRK6 Polyclonal Antibody | anti-GRK6 antibody

GRK6 Antibody FITC

Cat. Num. AAA5400415

• Gene Names: GRK6; GPRK6
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunoprecipitation, Western Blot
• Purity: Immobilized antigen affinity chromatography
• Synonyms: GRK6; Polyclonal Antibody; GRK6 Antibody FITC; FITC-Conjugated G protein-coupled receptor kinase 6 Antibody; G protein coupled receptor kinase 6 antibody; G protein coupled receptor kinase GRK6 antibody; Gprk6 antibody; Grk6 antibody; anti-GRK6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immobilized antigen affinity chromatography
• Concentration: 0.5-1.5 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 589

• Applicable Applications for anti-GRK6 antibody: ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: ELISA: 1:50,000; IP: 1:200; WB: 1:2,500-1:5,000
• Immunogen: Synthetic peptide taken within amino acid region 500-550 on human G protein-coupled receptor kinase 6 protein.
• Conjugation: FITC
• Molecular Function: ATP binding; beta-adrenergic receptor kinase activity; G-protein coupled receptor kinase activity
• Subcellular Location: Membrane; Lipid-anchor
• Preparation and Storage: Store at -20 degree C for long term storage.

Related Product Information for anti-GRK6 antibody

Overview: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Structure: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Expression: Widely expressed.

NCBI and Uniprot Product Information

• NCBI GI #: 51896035
• NCBI GeneID: 2870
• NCBI Accession #: NP_002073
• NCBI GenBank Nucleotide #: NM_002082.3
• UniProt Accession #: P43250; O60541; Q13652
• Molecular Weight: 64,294 Da
• NCBI Official Full Name: G protein-coupled receptor kinase 6 isoform B
• NCBI Official Synonym Full Names: G protein-coupled receptor kinase 6
• NCBI Official Symbol: GRK6
• NCBI Official Synonym Symbols: GPRK6
• NCBI Protein Information: G protein-coupled receptor kinase 6
• UniProt Protein Name: G protein-coupled receptor kinase 6
• Protein Family: G protein-coupled receptor kinase
• UniProt Gene Name: GRK6
• UniProt Synonym Gene Names: GPRK6

NCBI Description

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).