Immunohistochemistry (IHC)
(Anti-GRIK5 / KA2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.)
Goat GRIK5 / KA2 Polyclonal Antibody | anti-GRIK5 antibody
Goat Polyclonal to Human GRIK5 / KA2
Predicted Reactivity: Bovine (at least 90% immunogen sequence identity)
Predicted Reactivity: Bovine (at least 90% immunogen sequence identity)
Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Preliminary experiments gave an approx. 26kDa band in Human Brain (Frontal Cortex and Hippocampus) lysates after 1 ug/ml antibody staining. Please note that currently we can not...
Immunohistochemistry (IHC)
(Anti-GRIK5 / KA2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.)
Immunohistochemistry (IHC)
(Anti-GRIK5 / KA2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
GluR KA2: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; endoplasmic reticulum; dendrite; postsynaptic density; plasma membrane; terminal button; perikaryon; cell junction
Molecular Function: identical protein binding; extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; SH3 domain binding; PDZ domain binding
Biological Process: synaptic transmission; synaptic transmission, glutamatergic; ionotropic glutamate receptor signaling pathway; regulation of synaptic vesicle fusion to presynaptic membrane; positive regulation of neuron apoptosis; regulation of excitatory postsynaptic membrane potential; receptor clustering; protein retention in ER; establishment of cellular localization
Research Articles on GRIK5
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Product Notes
The GRIK5 grik5 (Catalog #AAA242979) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat Polyclonal to Human GRIK5 / KA2 reacts with Chimpanzee, Dog, Human Predicted Reactivity: Bovine (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's GRIK5 / KA2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), ELISA (EIA). ELISA (1:32000), IHC-P (3.75 ug/ml) Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Preliminary experiments gave an approx. 26kDa band in Human Brain (Frontal Cortex and Hippocampus) lysates after 1 ug/ml antibody staining. Please note that currently we can not.. Researchers should empirically determine the suitability of the GRIK5 grik5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRIK5 / KA2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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