Rabbit GRIA3 Polyclonal Antibody | anti-GRIA3 antibody

GRIA3 Polyclonal Antibody

Cat. Num. AAA3007733

• Gene Names: GRIA3; GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GRIA3; Polyclonal Antibody; GRIA3 Polyclonal Antibody; Glutamate receptor 3; GluR-3; AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic; AMPA 3; GluA3; GLUR3; GLURC; anti-GRIA3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GRIA3 polyclonal antibody detects endogenous levels of GRIA3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 894

• Applicable Applications for anti-GRIA3 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Recombinant full length Human GRIA3.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of GRIA3 polyclonal antibody in extracts from mouse brain tissue.)

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analysis of GRIA3 polyclonal antibody in paraffin-embedded Human Stomach Cancer tissue.)

Immunofluorescence (IF)

(Immunofluorescence analysis of U2OS cells, using GRIA3 polyclonal antibody)

Related Product Information for anti-GRIA3 antibody

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse.

NCBI and Uniprot Product Information

• NCBI GI #: 163659858
• NCBI GeneID: 2892
• NCBI Accession #: NP_000819.3
• NCBI GenBank Nucleotide #: NP_000819.3
• UniProt Accession #: P42263
• Molecular Weight: ~ 99kDa
• NCBI Official Full Name: glutamate receptor 3 isoform 2
• NCBI Official Synonym Full Names: glutamate ionotropic receptor AMPA type subunit 3
• NCBI Official Symbol: GRIA3
• NCBI Official Synonym Symbols: GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3
• NCBI Protein Information: glutamate receptor 3
• UniProt Protein Name: Glutamate receptor 3
• Protein Family: Glutamate receptor
• UniProt Gene Name: GRIA3
• UniProt Synonym Gene Names: GLUR3; GLURC; GluR-3; GluA3
• UniProt Entry Name: GRIA3_HUMAN

NCBI Description

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]