Testing Data
(Representative blot from a previous lot. Jurkat cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with MBS616558 (0.5ug/ml). Proteins were visualized using a goat antirabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates MBS616558 (40kD).)
Rabbit anti-Human, Mouse GRAP2 Polyclonal Antibody | anti-GRAP2 antibody
GRAP2 (GRB2 Related Adaptor Protein 2, GRB2 Like Protein, GADS, GRB2 Related Protein With Insert Domain, GRB2L, GRBLG, GrbX, Grf40, GRID, Growth Factor Receptor Binding Protein, GRPL, SH3-SH2-SH3 Adaptor Molecule) (PE)
Applications are based on unconjugated antibody.
Testing Data
(Representative blot from a previous lot. Jurkat cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with MBS616558 (0.5ug/ml). Proteins were visualized using a goat antirabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates MBS616558 (40kD).)
Testing Data
(Representative blot from a previous lot. Jurkat cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with MBS616558 (0.5ug/ml). Proteins were visualized using a goat antirabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates MBS616558 (40kD).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]
Uniprot Description
GADS: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. Belongs to the GRB2/sem-5/DRK family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol; endosome
Molecular Function: protein binding; SH3/SH2 adaptor activity
Biological Process: positive regulation of signal transduction; cell-cell signaling; Ras protein signal transduction; T cell costimulation; innate immune response; T cell receptor signaling pathway
Research Articles on GRAP2
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Product Notes
The GRAP2 grap2 (Catalog #AAA6478934) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GRAP2 (GRB2 Related Adaptor Protein 2, GRB2 Like Protein, GADS, GRB2 Related Protein With Insert Domain, GRB2L, GRBLG, GrbX, Grf40, GRID, Growth Factor Receptor Binding Protein, GRPL, SH3-SH2-SH3 Adaptor Molecule) (PE) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GRAP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). WB: 0.5-2ug/ml detects GRAP2 from a Jurkat RIPA cell lysate. Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the GRAP2 grap2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRAP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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