Western Blot (WB)
(NLRP6Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the NLRP6 antibody detected the NLRP6 protein (arrow).)
Rabbit anti-Human NLRP6 Polyclonal Antibody | anti-NLRP6 antibody
NLRP6 Antibody (N-term)
Western Blot (WB)
(NLRP6Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the NLRP6 antibody detected the NLRP6 protein (arrow).)
Western Blot (WB)
(NLRP6Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the NLRP6 antibody detected the NLRP6 protein (arrow).)
within the larger CATERPILLER protein family. Most short NALPs,
such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain
(PYD), followed by a NACHT domain, a NACHT-associated domain (NAD),
and a C-terminal leucine-rich repeat (LRR) region. The long NALP,
NALP1 (MIM 606636), also has a C-terminal extension containing a
function to find domain (FIIND) and a caspase recruitment domain
(CARD). NALPs are implicated in the activation of proinflammatory
caspases (e.g., CASP1; MIM 147678) via their involvement in
multiprotein complexes called inflammasomes (Tschopp et al., 2003
[PubMed 12563287]).
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Albrecht, M., et al. FEBS Lett. 538 (1-3), 173-177 (2003) :
Tschopp, J., et al. Nat. Rev. Mol. Cell Biol. 4(2):95-104(2003)
Grenier, J.M., et al. FEBS Lett. 530 (1-3), 73-78 (2002) :
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Uniprot Description
NLRP6: May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine- vasopressin but not angiotensin II and acts as an arginine- vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. Belongs to the NLRP family.
Protein type: Receptor, misc.
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: nuclear membrane; cytoplasm; plasma membrane
Molecular Function: ATP binding; vasopressin receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; wound healing; response to bacterium; negative regulation of MAPKKK cascade; negative regulation of immune response; regulation of inflammatory response; negative regulation of toll-like receptor signaling pathway; regulation of autophagy; negative regulation of I-kappaB kinase/NF-kappaB cascade
Research Articles on NLRP6
Similar Products
Product Notes
The NLRP6 nlrp6 (Catalog #AAA9207781) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 168-197. The NLRP6 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NLRP6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the NLRP6 nlrp6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NLRP6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
