Rabbit anti-Human GRAF Polyclonal Antibody | anti-ARHGAP26 antibody

GRAF, CT (GTPase Regulator Associated with Focal Adhesion Kinase, ARHGAP26, FLJ42530, KIAA0621, Oligophrenin-1-like Protein, OPHN1L, OPHN1L1, Rho GTPase Activating Protein 26, Rho-type GTPase-activating Protein 26)

Cat. Num. AAA643932

• Gene Names: ARHGAP26; GRAF; GRAF1; OPHN1L; OPHN1L1
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: GRAF; Polyclonal Antibody; CT (GTPase Regulator Associated with Focal Adhesion Kinase; ARHGAP26; FLJ42530; KIAA0621; Oligophrenin-1-like Protein; OPHN1L; OPHN1L1; Rho GTPase Activating Protein 26; Rho-type GTPase-activating Protein 26); Anti -GRAF; anti-ARHGAP26 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human OPHN1L.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.09% sodium azide.

• Applicable Applications for anti-ARHGAP26 antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA and Immunohistochemistry.; Dilution: ELISA: 1:1,000; Immunohistochemistry: 1:50-1:100
• Immunogen: Synthetic peptide selected from the C-terminal region of human OPHN1L (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-ARHGAP26 antibody

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.

Product Categories/Family for anti-ARHGAP26 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 21541528
• NCBI GeneID: 23092
• UniProt Accession #: Q9UNA1; O75117; Q5D035; Q9BYS6; Q9BYS7; Q9UJ00
• Molecular Weight: 92,235 Da
• NCBI Official Full Name: GRAF
• NCBI Official Synonym Full Names: Rho GTPase activating protein 26
• NCBI Official Symbol: ARHGAP26
• NCBI Official Synonym Symbols: GRAF; GRAF1; OPHN1L; OPHN1L1
• NCBI Protein Information: rho GTPase-activating protein 26; oligophrenin-1-like protein; GTPase regulator associated with focal adhesion kinase pp125(FAK)
• UniProt Protein Name: Rho GTPase-activating protein 26
• Protein Family: Rho GTPase-activating protein
• UniProt Gene Name: ARHGAP26
• UniProt Synonym Gene Names: GRAF; KIAA0621; OPHN1L
• UniProt Entry Name: RHG26_HUMAN

NCBI Description

Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Uniprot Description

ARHGAP26: GTPase-activating protein for RHOA and CDC42. Interacts with NYAP1, NYAP2 and MYO16. Binds to the C-terminus of PTK2/FAK1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Oncoprotein; GAPs; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: focal adhesion; cytoskeleton; cytosol

Molecular Function: protein binding; phospholipid binding

Biological Process: nervous system development; regulation of small GTPase mediated signal transduction; plasma membrane organization and biogenesis; small GTPase mediated signal transduction; actin cytoskeleton organization and biogenesis

Disease: Juvenile Myelomonocytic Leukemia