Rabbit GPRC5C Polyclonal Antibody | anti-GPRC5C antibody

Rabbit Polyclonal to Human GPRC5C

Cat. Num. AAA243654

• Gene Names: GPRC5C; RAIG3; RAIG-3
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon, Rat, Bovine, Hamster, Horse (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GPRC5C; Polyclonal Antibody; Rabbit Polyclonal to Human GPRC5C; Anti-GPRC5C Antibody (Extracellular Domain) IHC-plus; RAIG-3; RAIG3; Human GPRC5C; anti-GPRC5C antibody

• Host: Rabbit
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon, Rat, Bovine, Hamster, Horse (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human GPRC5C. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 453

• Applicable Applications for anti-GPRC5C antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (36 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from 3rd extracellular domain of human GPRC5C. Percent identity with other species by BLAST analysis: Human, Gorilla, Elephant (100%); Gibbon, Rat, Hamster, Dolphin, Bovine, Horse (94%).
• Immunogen Type: Synthetic peptide
• Immunogen: GPRC5C antibody was raised against synthetic 18 amino acid peptide from 3rd extracellular domain of human GPRC5C. Percent identity with other species by BLAST analysis: Human, Gorilla, Elephant (100%); Gibbon, Rat, Hamster, Dolphin, Bovine, Horse (94%); Monkey, Marmoset, Mouse, Panda, Dog, Rabbit, Opossum (89%); Pig (83%).
• Antigen Modification: Extracellular Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GPRC5C antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPRC5C antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPRC5C antibody IHC of human stomach, muscularis propria. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPRC5C antibody IHC of human pancreas, carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GPRC5C antibody

GPRC5C is an Orphan-C GPCR induced by retinoids.

Product Categories/Family for anti-GPRC5C antibody

Family: GPCR; Subfamily: Orphan-C

NCBI and Uniprot Product Information

• NCBI GI #: 40217833
• NCBI GeneID: 55890
• NCBI Accession #: NP_061123.3
• NCBI GenBank Nucleotide #: NM_018653.3
• UniProt Accession #: Q9NQ84; Q2NL85; Q9NZG5; B5BUN4
• Molecular Weight: 49,389 Da
• NCBI Official Full Name: G-protein coupled receptor family C group 5 member C isoform b
• NCBI Official Synonym Full Names: G protein-coupled receptor, class C, group 5, member C
• NCBI Official Symbol: GPRC5C
• NCBI Official Synonym Symbols: RAIG3; RAIG-3
• NCBI Protein Information: G-protein coupled receptor family C group 5 member C; orphan G-protein coupled receptor; retinoic acid-induced gene 3 protein; retinoic acid responsive gene protein; G protein-coupled receptor, family C, group 5, member C
• UniProt Protein Name: G-protein coupled receptor family C group 5 member C
• Protein Family: G-protein coupled receptor family
• UniProt Gene Name: GPRC5C
• UniProt Synonym Gene Names: RAIG3; RAIG-3
• UniProt Entry Name: GPC5C_HUMAN

NCBI Description

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GPRC5C: This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 3

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: cytoplasmic vesicle membrane; mitochondrion; integral to plasma membrane; receptor complex; vesicle

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway