Rabbit GPR56 Polyclonal Antibody | anti-GPR56 antibody
GPR56 Extracellular domain Antibody FITC
Predicted: Rat
Predicted: Rat
ELISA: 1:20,000-1:50,000
Immunohistochemistry: 1:100
Western Blot: 1:500-1:750
Involved in cell adhesion and probably in cell-cell interactions.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Description
GPR56: Could be involved in cell-cell interactions. Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP). BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 2
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: integral to membrane; integral to plasma membrane; intracellular
Molecular Function: collagen binding; extracellular matrix binding; G-protein coupled receptor activity
Biological Process: angiogenesis; brain development; cell adhesion; cell surface receptor linked signal transduction; cell-cell signaling; cerebral cortex radial glia guided migration; cerebral cortex regionalization; G-protein coupled receptor protein signaling pathway; layer formation in the cerebral cortex; negative regulation of cell proliferation; positive regulation of cell adhesion; positive regulation of Rho protein signal transduction; Rho protein signal transduction
Disease: Polymicrogyria, Bilateral Frontoparietal; Polymicrogyria, Bilateral Perisylvian, Autosomal Recessive
Research Articles on GPR56
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Product Notes
The GPR56 adgrg1 (Catalog #AAA541753) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GPR56 Extracellular domain Antibody FITC reacts with Human, Monkey, Mouse Predicted: Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GPR56 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). Dot Blot: 1:20,000-1:50,000 ELISA: 1:20,000-1:50,000 Immunohistochemistry: 1:100 Western Blot: 1:500-1:750. Researchers should empirically determine the suitability of the GPR56 adgrg1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GPR56, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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