Rabbit anti-Human, Mouse GPR179 Polyclonal Antibody | anti-GPR179 antibody

GPR179 Polyclonal Antibody

Cat. Num. AAA3006624

• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GPR179; Polyclonal Antibody; GPR179 Polyclonal Antibody; Probable G-protein coupled receptor 179; Probable G-protein coupled receptor 158-like 1; GPR158-like; GPR158L; GPR158L1; anti-GPR179 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GPR179 polyclonal antibody detects endogenous levels of GPR179 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 2367

• Applicable Applications for anti-GPR179 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human GPR179.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of GPR179 polyclonal antibody at 1:500 dilutionLane1:Hela cell lysateLane2:sp2/0 cell lysate)

Related Product Information for anti-GPR179 antibody

Probable G-protein coupled receptor 179 is a protein that in humans is encoded by the GPR179 gene. This gene encodes a member of the glutamate receptor subfamily of G protein-coupled receptors. The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein. Mutations in this gene are associated with congenital stationary night blindness type 1E.

NCBI and Uniprot Product Information

• NCBI GI #: 629266054
• NCBI Accession #: NP_001004334.3
• NCBI GenBank Nucleotide #: NP_001004334.3
• UniProt Accession #: Q6PRD1
• Molecular Weight: ~ 257kDa
• NCBI Official Full Name: probable G-protein coupled receptor 179
• UniProt Protein Name: Probable G-protein coupled receptor 179
• Protein Family: Probable G-protein coupled receptor
• UniProt Gene Name: GPR179
• UniProt Synonym Gene Names: GPR158L; GPR158L1; GPR158-like

Uniprot Description

GPR179: Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. Defects in GPR179 are the cause of congenital stationary night blindness type 1E (CSNB1E). An autosomal recessive, non-progressive retinal disorder characterized by impaired night vision, absence of the electroretinogram (ERG) b- wave, and variable degrees of involvement of other visual functions. Affected individuals have an ERG waveform that lacks the b-wave because of failure to transmit the photoreceptor signal through the retinal depolarizing bipolar cells. Belongs to the G-protein coupled receptor 3 family.

Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: integral component of membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor signaling pathway; visual perception

Disease: Night Blindness, Congenital Stationary, Type 1e