Rabbit GPR143 Polyclonal Antibody | anti-GPR143 antibody

Rabbit Polyclonal to Human GPR143

Cat. Num. AAA247581

• Gene Names: GPR143; OA1; NYS6
• Reactivity: Gorilla, Human
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GPR143; Polyclonal Antibody; Rabbit Polyclonal to Human GPR143; Anti-GPR143 Antibody (C-Terminus) IHC-plus; G-protein coupled receptor 143; G protein-coupled receptor 143; NYS6; OA1; Ocular albinism 1; Ocular albinism type 1 protein; Human GPR143; anti-GPR143 antibody

• Host: Rabbit
• Reactivity: Gorilla, Human
• Clonality: Polyclonal
• Specificity: Human GPR143. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 404

• Applicable Applications for anti-GPR143 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (6 - 14 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 16 amino acid peptide from C-terminus of human GPR143. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (88%).
• Immunogen Type: Synthetic peptide
• Immunogen: GPR143 antibody was raised against synthetic 16 amino acid peptide from C-terminus of human GPR143. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey, Marmoset (88%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GPR143 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPR143 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPR143 antibody IHC of human eye, retina. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPR143 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GPR143 antibody

Ocular albinism 1 (Nettleship-Falls; OA1) is an Orphan-U GPCR with an unknown ligand. Ocular albinism type 1 (OA1) is an inherited disorder characterized by severe reduction of visual acuity, photophobia, and retinal hypopigmentation. Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. Misfolding of the OA1 protein has been suggested as a major pathogenic mechanism in OA1.

Product Categories/Family for anti-GPR143 antibody

Family: GPCR; Subfamily: Orphan-U

NCBI and Uniprot Product Information

• NCBI GI #: 270265839
• NCBI GeneID: 4935
• NCBI Accession #: NP_000264.2
• NCBI GenBank Nucleotide #: NM_000273.2
• UniProt Accession #: P51810; Q6NTI7
• Molecular Weight: 43,878 Da
• NCBI Official Full Name: G-protein coupled receptor 143
• NCBI Official Synonym Full Names: G protein-coupled receptor 143
• NCBI Official Symbol: GPR143
• NCBI Official Synonym Symbols: OA1; NYS6
• NCBI Protein Information: G-protein coupled receptor 143; ocular albinism 1; ocular albinism type 1 protein
• UniProt Protein Name: G-protein coupled receptor 143
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR143
• UniProt Synonym Gene Names: OA1
• UniProt Entry Name: GP143_HUMAN

NCBI Description

This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]

Uniprot Description

GPR143: Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. Defects in GPR143 are the cause of albinism ocular type 1 (OA1); also known as Nettleship-Falls type ocular albinism. Form of albinism affecting only the eye. Pigment of the hair and skin is normal or only slightly diluted. Eyes may be severely affected with photophobia and reduced visual acuity. Nystagmus or strabismus are often associated. The irides and fundus are depigmented. Defects in GPR143 are the cause of Nystagmus congenital X-linked type 6 (NYS6). It is a condition defined as conjugated, spontaneous and involuntary ocular oscillations that appear at birth or during the first three months of life. Other associated features may include mildly decreased visual acuity, strabismus, astigmatism, and occasionally head nodding. Belongs to the G-protein coupled receptor OA family.

Protein type: GPCR, OA family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xp22.3

Cellular Component: Golgi apparatus; membrane; lysosomal membrane; cytoplasm; apical plasma membrane; melanosome membrane; plasma membrane; melanosome; integral to membrane

Molecular Function: G-protein coupled receptor activity; protein binding; dopamine binding

Biological Process: G-protein coupled receptor protein signaling pathway; phosphoinositide-mediated signaling; visual perception; neuropeptide signaling pathway; melanosome organization and biogenesis; melanosome localization; regulation of calcium-mediated signaling; signal transduction; melanosome transport; eye pigment biosynthetic process

Disease: Nystagmus 6, Congenital, X-linked; Albinism, Ocular, Type I