Rabbit GPD1 Polyclonal Antibody | anti-GPD1 antibody

GPD1 Rabbit Polyclonal

Cat. Num. AAA769811

• Gene Names: GPD1; GPD-C; HTGTI; GPDH-C
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: GPD1; Polyclonal Antibody; GPD1 Rabbit Polyclonal; anti-GPD1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 326

• Applicable Applications for anti-GPD1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Glycerol-3-phosphate dehydrogenase 1 (soluble)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat heart using MBS769811 (GPD1 antibody) at dilution of 1:100)

Western Blot (WB)

(mouse kidney tissue were subjected to SDS PAGE followed by western blot with MBS769811 (GPD1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 380714668
• NCBI GeneID: 2819
• NCBI Accession #: NP_001244128.1
• NCBI GenBank Nucleotide #: NM_001257199.1
• Molecular Weight: 35,140 Da
• NCBI Official Full Name: glycerol-3-phosphate dehydrogenase
• NCBI Official Synonym Full Names: glycerol-3-phosphate dehydrogenase 1
• NCBI Official Symbol: GPD1
• NCBI Official Synonym Symbols: GPD-C; HTGTI; GPDH-C
• NCBI Protein Information: glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
• UniProt Protein Name: Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
• Protein Family: Glycerol-3-phosphate dehydrogenase
• UniProt Gene Name: GPD1
• UniProt Synonym Gene Names: GPD-C; GPDH-C
• UniProt Entry Name: GPDA_HUMAN

NCBI Description

This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Uniprot Description

GPD1: Defects in GPD1 are a cause of hypertriglyceridemia, transient infantile (HTGTI). An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis. Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Protein type: Lipid Metabolism - glycerophospholipid; EC 1.1.1.8; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: cytosol; glycerol-3-phosphate dehydrogenase complex; mitochondrion

Molecular Function: glycerol-3-phosphate dehydrogenase (NAD+) activity; glycerol-3-phosphate dehydrogenase activity; NAD binding; protein homodimerization activity

Biological Process: gluconeogenesis; glycerol-3-phosphate catabolic process; glycerophosphate shuttle; phosphatidic acid biosynthetic process; positive regulation of glycolysis; triacylglycerol biosynthetic process

Disease: Hypertriglyceridemia, Transient Infantile