Testing Data
(Staining of permeabilised mouse peritoneal macrophages with C2423-05P1.)
Rat anti-Mouse CD68 Monoclonal Antibody | anti-CD68 antibody
CD68 (DKFZp686M18236, GP110, Macrophage Antigen CD68 (Microsialin), Macrosialin, Scavenger Receptor Class D Member 1, SCARD1) (MaxLight 750)
Gene Names
Cd68; Lamp4; gp110; Scard1
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Purity
Purified by protein G affinity chromatography from tissue culture supernatant.
Synonyms
CD68; Monoclonal Antibody; CD68 (DKFZp686M18236; GP110; Macrophage Antigen CD68 (Microsialin); Macrosialin; Scavenger Receptor Class D Member 1; SCARD1) (MaxLight 750); CD68 Antigen; CD68 Molecule; Monocytes/Macrophages; anti-CD68 antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
10B1906
Specificity
Recognizes mouse CD68. Detects surface macrosialin at low levels in resident mouse peritoneal macrophages which can be enhanced with thioglycollate stimulation.
Purity/Purification
Purified by protein G affinity chromatography from tissue culture supernatant.
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight750.
Applicable Applications for anti-CD68 antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Immunogen
Purified Concanavalin A acceptor glycoprotein from P815 cell line
Conjugate
MaxLight750
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Testing Data
(Staining of permeabilised mouse peritoneal macrophages with C2423-05P1.)
Testing Data
(Staining of permeabilised mouse peritoneal macrophages with C2423-05P1.)
Testing Data
(Staining of permeabilised mouse peritoneal macrophages with RAT ANTI MOUSE CD68: RPE)
Testing Data
(Staining of permeabilised mouse peritoneal macrophages with RAT ANTI MOUSE CD68: RPE)
Testing Data
(Staining of permeabilised mouse peritoneal macrophages with RAT ANTI MOUSE CD68:Alexa Fluor® 647)
Testing Data
(Staining of permeabilised mouse peritoneal macrophages with RAT ANTI MOUSE CD68:Alexa Fluor® 647)
Product Categories/Family for anti-CD68 antibody
References
1. Ramprasad, M.P. et al. (1996) Proc. Natl. Acad. Sci. 93: 14833-14838. 2. Rabinowitz, S.S. & Gordon, S. (1991) J. Exp. Med. 174: 827-836. 3. Da Silva, R.P & Gordon, S. (1999) Biochem. J. 338: 687-694. 4. Schleicher, U. et al. (2005). Blood 105: 1319-1328.5. von Lukowicz, T. et al. (2008) P PloS ONE 5: e13424.7. Rahaman, S.O. et al. (2011) J Biol Chem. Jan 5. 8. Frossard, J.L. et al. (2011) J Clin Pathol. Feb 23. 9. West, E.L. et al. (2010) Stem Cells. 28: 1997-2007. 10. Lopez, M.E. et al. (2011) J Neurosci. 31: 4367-78. 11. Jayagopal, A. et al. (2009) Nanotechnology. 20: 165102. 12. Leung, V.W. et al. (2009) Am J Pathol. 175: 1757-67. 13. Devey, L. et al. (2009) Mol Ther. 17: 65-72. 14. Lu, W. et al. (2010) Biomaterials. 31: 2617-26. 15. de Beer, M.C. et al. (2003) J Lipid Res. 44: 674- 85. 16. Song, L. et al. (2011) J Lipid Res. 52: 1542-50. 17. Daldrup-Link, H.E. et al. (2011)Clin Cancer Res. Jul 26. 18. Macauley, S.L. et al. (2011)J. Neurosci 31: 15575-85 19. Martin-Manso, G. et al. (2008) Cancer Res. 68: 7090-9. 20. Lazarini, F. et al. (2012) J Neurosci 32: 3652-64. 21. Hemmi, H. et al. (2009) J Immunol. 182: 1278-86. 22. Akbarshahi, H. et al. (2012) PLoS One. 7: e42654.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
33,844 Da
NCBI Official Full Name
Macrosialin
NCBI Official Synonym Full Names
CD68 antigen
NCBI Official Symbol
Cd68
NCBI Official Synonym Symbols
Lamp4; gp110; Scard1
NCBI Protein Information
macrosialin
UniProt Protein Name
Macrosialin
Protein Family
UniProt Gene Name
Cd68
UniProt Entry Name
CD68_MOUSE
Uniprot Description
CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface; Membrane protein, integral
Cellular Component: membrane; lysosome; integral to membrane; plasma membrane; endosome
Research Articles on CD68
Similar Products
Product Notes
The CD68 cd68 (Catalog #AAA6256799) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The CD68 (DKFZp686M18236, GP110, Macrophage Antigen CD68 (Microsialin), Macrosialin, Scavenger Receptor Class D Member 1, SCARD1) (MaxLight 750) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD68 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). Researchers should empirically determine the suitability of the CD68 cd68 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD68, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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