Rabbit GPBB / PYGB Polyclonal Antibody | anti-GPBB antibody

Rabbit Polyclonal to Human GPBB / PYGB

Cat. Num. AAA247755

• Gene Names: PYGB; GPBB
• Reactivity: Gibbon, Gorilla, Human, Monkey, Rabbit; Predicted Reactivity: Orangutan, Mouse, Rat, Dog, Hamster, Horse (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GPBB / PYGB; Polyclonal Antibody; Rabbit Polyclonal to Human GPBB / PYGB; Anti-GPBB / PYGB Antibody (C-Terminus) IHC-plus; PYGB; GPBB; Phosphorylase; glycogen; glycogen brain; Glycogen phosphorylase B; Human GPBB; anti-GPBB antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human, Monkey, Rabbit; Predicted Reactivity: Orangutan, Mouse, Rat, Dog, Hamster, Horse (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human PYGB. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 843

• Applicable Applications for anti-GPBB antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (10 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 12 amino acid peptide from C-terminus of human PYGB.
• Immunogen Type: Synthetic peptide
• Immunogen: GPBB / PYGB antibody was raised against synthetic 12 amino acid peptide from C-terminus of human PYGB. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rabbit (100%); Orangutan, Mouse, Rat, Dog, Hamster, Elephant, Panda, Horse (92%); Turkey, Chicken, Platypus, Xenopus (83%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-PYGB antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

NCBI and Uniprot Product Information

• NCBI GI #: 21361370
• NCBI GeneID: 5834
• NCBI Accession #: NP_002853.2
• NCBI GenBank Nucleotide #: NM_002862.3
• UniProt Accession #: P11216; Q96AK1; Q9NPX8
• Molecular Weight: 96,696 Da
• NCBI Official Full Name: glycogen phosphorylase, brain form
• NCBI Official Synonym Full Names: phosphorylase, glycogen; brain
• NCBI Official Symbol: PYGB
• NCBI Official Synonym Symbols: GPBB
• NCBI Protein Information: glycogen phosphorylase, brain form; glycogen phosphorylase B
• UniProt Protein Name: Glycogen phosphorylase, brain form
• UniProt Gene Name: PYGB
• UniProt Entry Name: PYGB_HUMAN

NCBI Description

The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]

Uniprot Description

PYGB: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. Belongs to the glycogen phosphorylase family.

Protein type: Phosphorylase; Carbohydrate Metabolism - starch and sucrose; Kinase, other; EC 2.4.1.1; Transferase

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: membrane; cytoplasm

Molecular Function: glycogen phosphorylase activity; pyridoxal phosphate binding

Biological Process: glycogen catabolic process; carbohydrate metabolic process; glucose metabolic process; pathogenesis