Western Blot (WB)
(GP6 Antibody (C-term) western blot analysis in K562 cell line lysates (15ug/lane).This demonstrates the GP6 antibody detected the GP6 protein (arrow).)
Rabbit anti-Human GP6 Polyclonal Antibody | anti-GP6 antibody
GP6 Antibody (C-term)
Western Blot (WB)
(GP6 Antibody (C-term) western blot analysis in K562 cell line lysates (15ug/lane).This demonstrates the GP6 antibody detected the GP6 protein (arrow).)
Western Blot (WB)
(GP6 Antibody (C-term) western blot analysis in K562 cell line lysates (15ug/lane).This demonstrates the GP6 antibody detected the GP6 protein (arrow).)
Flow Cytometry (FC/FACS)
(GP6 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(GP6 Antibody (C-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
glycoprotein that plays a crucial role in the collagen-induced
activation and aggregation of platelets. Upon injury to the vessel
wall and subsequent damage to the endothelial lining, exposure of
the subendothelial matrix to blood flow results in deposition of
platelets. Collagen fibers are the most thrombogenic macromolecular
components of the extracellular matrix, with collagen types I, III,
and VI being the major forms found in blood vessels. Platelet
interaction with collagen occurs as a 2-step procedure: (1) the
initial adhesion to collagen is followed by (2) an activation step
leading to platelet secretion, recruitment of additional platelets,
and aggregation. In physiologic conditions, the resulting platelet
plug is the initial hemostatic event limiting blood loss. However,
exposure of collagen after rupture of atherosclerotic plaques is a
major stimulus of thrombus formation associated with myocardial
infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed
10961879]).
Asselin, J., et al. Blood 89(4):1235-1242(1997)
Huang, M.M., et al. Proc. Natl. Acad. Sci. U.S.A. 88(17):7844-7848(1991)
Moroi, M., et al. J. Clin. Invest. 84(5):1440-1445(1989)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
GPVI: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. Defects in GP6 are the cause of bleeding disorder platelet-type 11 (BDPLT11). BDPLT11 is a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: cell surface; integral to plasma membrane; plasma membrane
Molecular Function: collagen binding; protein binding; transmembrane receptor activity; receptor activity
Biological Process: platelet activation; blood coagulation; enzyme linked receptor protein signaling pathway; leukocyte migration
Disease: Bleeding Disorder, Platelet-type, 11
Research Articles on GP6
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Product Notes
The GP6 gp6 (Catalog #AAA9211313) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 309-337. The GP6 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GP6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the GP6 gp6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GP6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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