Rabbit anti-Human, Mouse GORAB Polyclonal Antibody | anti-GORAB antibody

GORAB, NT (GORAB, NTKLBP1, SCYL1BP1, RAB6-interacting golgin, N-terminal kinase-like-binding protein 1, SCY1-like 1-binding protein 1) (APC)

Cat. Num. AAA6303283

• Gene Names: GORAB; GO; NTKLBP1; SCYL1BP1
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: GORAB; Polyclonal Antibody; NT (GORAB; NTKLBP1; SCYL1BP1; RAB6-interacting golgin; N-terminal kinase-like-binding protein 1; SCY1-like 1-binding protein 1) (APC); SCY1-like 1-binding protein 1; anti-GORAB antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-GORAB antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: GORAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31~60 amino acids from the N-terminal region of human GORAB.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of GORAB Antibody (N-term) in CHO cell line lysates (35ug/lane). GORAB (arrow) was detected using the purified Pab;)

Western Blot (WB)

(Western blot analysis of GORAB Antibody (N-term) in mouse NIH-3T3 cell line lysates (35ug/lane). GORAB (arrow) was detected using the purified Pab.)

Related Product Information for anti-GORAB antibody

GORAB encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis.

Product Categories/Family for anti-GORAB antibody

Antibodies; GTPase; Rab; Ras; Rho Proteins

References

Kim, J., et.al., Life Sci. 86 (9-10), 300-308 (2010). Al-Dosari, M. et.al., Am. J. Med. Genet. A 149A (10), 2093-2098 (2009).

NCBI and Uniprot Product Information

• NCBI GI #: 74745442
• NCBI GeneID: 92344
• UniProt Accession #: Q5T7V8; Q49A22; Q6P1P9; Q9HAE6; Q9Y350
• Molecular Weight: 24,652 Da
• NCBI Official Full Name: RAB6-interacting golgin
• NCBI Official Synonym Full Names: golgin, RAB6-interacting
• NCBI Official Symbol: GORAB
• NCBI Official Synonym Symbols: GO; NTKLBP1; SCYL1BP1
• NCBI Protein Information: RAB6-interacting golgin; SCYL1-BP1; hNTKL-BP1; NTKL-binding protein 1; SCYL1-binding protein 1; SCY1-like 1 binding protein 1; SCY1-like 1-binding protein 1; N-terminal kinase-like-binding protein 1
• UniProt Protein Name: RAB6-interacting golgin
• Protein Family: RAB6-interacting golgin
• UniProt Gene Name: GORAB
• UniProt Synonym Gene Names: NTKLBP1; SCYL1BP1; NTKL-BP1; NTKL-binding protein 1; hNTKL-BP1; SCYL1-BP1; SCYL1-binding protein 1
• UniProt Entry Name: GORAB_HUMAN

NCBI Description

This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Uniprot Description

SCYL1BP1: Defects in GORAB are the cause of geroderma osteodysplasticum (GO); also known as gerodermia osteodysplastica or Walt Disney dwarfism. GO is a rare autosomal recessive disorder characterized by lax, wrinkled skin, joint laxity and a typical face with a prematurely aged appearance. Skeletal signs include severe osteoporosis leading to frequent fractures, malar and mandibular hypoplasia and a variable degree of growth retardation. Belongs to the GORAB family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding

Disease: Geroderma Osteodysplasticum