Rabbit GNAZ Polyclonal Antibody | anti-GNAZ antibody

Rabbit Anti Human GNAZ PolyClonal Antibody

Cat. Num. AAA1491215

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purification
• Synonyms: GNAZ; Polyclonal Antibody; Rabbit Anti Human GNAZ PolyClonal Antibody; Gz-alpha; G(x) alpha chain; Guanine nucleotide-binding protein G(z) subunit alpha; anti-GNAZ antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Sequence Length: 355

• Applicable Applications for anti-GNAZ antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Recombinant protein of human GNAZ
• Relevance: Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of alpha, beta and gamma subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Galpha subunits have been classified into four families, Galpha(s), Galpha(i/o), Galpha(q) and Galpha(12), based on structural and functional similarities. Phosphorylation of Tyr356 of Galpha(q)/Galpha(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Galpha with receptors and abolishes ligand-induced IP3 formation.Galpha(z) stands out from other G proteins because it lacks an ADP-ribosylation consensus site for pertussis toxin, giving it a possible role in signal transduction pathways resistant to the toxin, such as phospholipase C. Galpha(z) is phosphorylated and activated by protein kinase C (PKC) at Ser27.
• Storage Buffer: Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

NCBI and Uniprot Product Information

• NCBI GI #: 47678521
• NCBI GeneID: 2781
• UniProt Accession #: P19086; Q4QRJ6; B2R6C1
• Molecular Weight: 40,924 Da
• NCBI Official Full Name: GNAZ
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), alpha z polypeptide
• NCBI Official Symbol: GNAZ
• NCBI Protein Information: guanine nucleotide-binding protein G(z) subunit alpha; guanine nucleotide-binding protein G(z) subunit alpha; gz-alpha; g(x) alpha chain; transducin alpha
• UniProt Protein Name: Guanine nucleotide-binding protein G(z) subunit alpha
• UniProt Gene Name: GNAZ
• UniProt Entry Name: GNAZ_HUMAN

NCBI Description

The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

Uniprot Description

G-alpha(z): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Protein type: Nuclear envelope; Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))

Chromosomal Location of Human Ortholog: 22q11.22

Cellular Component: endoplasmic reticulum; plasma membrane; heterotrimeric G-protein complex; nuclear envelope; cytosol

Molecular Function: GTPase activity; signal transducer activity; GTP binding; metal ion binding; receptor signaling protein activity; G-protein beta/gamma-subunit binding; metabotropic serotonin receptor binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; metabolic process; G-protein signaling, adenylate cyclase inhibiting pathway