Rabbit anti-Human, Mouse GNAT1 Polyclonal Antibody | anti-GNAT1 antibody

GNAT1 Antibody

Cat. Num. AAA9412887

• Gene Names: GNAT1; GBT1; GNATR; CSNB1G; CSNBAD3
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: GNAT1; Polyclonal Antibody; GNAT1 Antibody; GBT1; GNATR; guanine nucleotide-binding protein G; transducin alpha-1 ch; anti-GNAT1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total GNAT1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 350

• Applicable Applications for anti-GNAT1 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:3000
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human GNAT1.
• Target Name: GNAT1
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from COLO cells, using GNAT1 antibody.)

Related Product Information for anti-GNAT1 antibody

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.Fong S.-L.; Nucleic Acids Res. 20:2865-2870(1992).Lerea C.L., Neuron 3:367-376(1989).van Dop C., Nucleic Acids Res. 17:4887-4887(1989).

Product Categories/Family for anti-GNAT1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 22027520
• NCBI GeneID: 2779
• NCBI Accession #: NP_000163.2
• NCBI GenBank Nucleotide #: NM_000172.3
• UniProt Accession #: P11488; Q4VBN2
• Molecular Weight: 40,041 Da
• NCBI Official Full Name: guanine nucleotide-binding protein G(t) subunit alpha-1
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
• NCBI Official Symbol: GNAT1
• NCBI Official Synonym Symbols: GBT1; GNATR; CSNB1G; CSNBAD3
• NCBI Protein Information: guanine nucleotide-binding protein G(t) subunit alpha-1
• UniProt Protein Name: Guanine nucleotide-binding protein G(t) subunit alpha-1
• UniProt Gene Name: GNAT1
• UniProt Synonym Gene Names: GNATR
• UniProt Entry Name: GNAT1_HUMAN

NCBI Description

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. This gene is also expressed in other cells, and has been implicated in bitter taste transduction in rat taste cells. Mutations in this gene result in autosomal dominant congenital stationary night blindness. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]

Uniprot Description

G-alpha t1: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. Defects in GNAT1 are the cause of congenital stationary night blindness autosomal dominant type 3 (CSNBAD3); also known as congenital stationary night blindness Nougaret type. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Protein type: G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G((i/o/t/z))

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: photoreceptor inner segment; photoreceptor outer segment; membrane; cell soma; apical plasma membrane; plasma membrane; heterotrimeric G-protein complex; cytosol; photoreceptor connecting cilium

Molecular Function: GTPase activity; signal transducer activity; GDP binding; acyl binding; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; protein kinase binding

Biological Process: phototransduction, visible light; response to light stimulus; sensory perception of umami taste; metabolic process; response to light intensity; detection of chemical stimulus involved in sensory perception of bitter taste; signal transduction; rhodopsin mediated signaling; G-protein signaling, coupled to cAMP nucleotide second messenger; cell proliferation; eye photoreceptor cell development; regulation of rhodopsin mediated signaling; visual perception; retina development in camera-type eye; detection of light stimulus involved in visual perception; positive regulation of cyclic-nucleotide phosphodiesterase activity; negative regulation of cyclic-nucleotide phosphodiesterase activity

Disease: Night Blindness, Congenital Stationary, Type 1g; Night Blindness, Congenital Stationary, Autosomal Dominant 3