Rabbit Glycogen Synthase Polyclonal Antibody | anti-GYS2 antibody

Glycogen Synthase antibody

Cat. Num. AAA5300915

• Applications: Western Blot, ELISA
• Synonyms: Glycogen Synthase; Polyclonal Antibody; Glycogen Synthase antibody; Polyclonal Glycogen Synthase; Anti-Glycogen Synthase; UDP-glucose-glycogen glucosyltransferase;; anti-GYS2 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Glycogen Synthase antibody detects endogenous levels of total Glycogen Synthase protein
• Form/Format: Supplied in PBS buffer (without Mg2+and Ca2+), pH 7.4, 150mM NaCl with 0.02% sodium azide and 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 703

• Applicable Applications for anti-GYS2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:1000; ELISA: 1:1000
• Biological Significance: Glycogen Synthase regulates glycogen/glucose levels and is activated by dephosphorylation.
• Cross-Reactivity: Mouse
• Immunogen: Glycogen Synthase antibody was raised in Rabbit using synthesized non-phosphopeptide derived from human Glycogen Synthase around the phosphorylation site of serine 641 (P-A-SP-V-P) as the immunogen
• Preparation and Storage: Aliquot and store at -20 degree C. Avoid repeated freeze thaw cycles

Western Blot (WB)

(Western blot analysis of extracts from HeLa cells, using Glycogen Synthase antibody)

Related Product Information for anti-GYS2 antibody

Rabbit polyclonal Glycogen Synthase antibody

Product Categories/Family for anti-GYS2 antibody

Proteases; Inhibitors; & Enzymes; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 546961
• NCBI GeneID: 2998
• Molecular Weight: 80,989 Da
• NCBI Official Full Name: glycogen synthase
• NCBI Official Synonym Full Names: glycogen synthase 2 (liver)
• NCBI Official Symbol: GYS2
• NCBI Protein Information: glycogen [starch] synthase, liver
• UniProt Protein Name: Glycogen [starch] synthase, liver
• Protein Family: Glycogen synthase
• UniProt Gene Name: GYS2
• UniProt Entry Name: GYS2_HUMAN

NCBI Description

The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. [provided by RefSeq, Dec 2009]

Uniprot Description

GYS2: Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. Defects in GYS2 are the cause of glycogen storage disease type 0 (GSD0); A metabolic disorder characterized by fasting hypoglycemia presenting in infancy or early childhood, high blood ketones and low alanine and lactate concentrations. Although feeding relieves symptoms, it often results in postprandial hyperglycemia and hyperlactatemia. Belongs to the glycosyltransferase 3 family.

Protein type: EC 2.4.1.11; Transferase; Cytoskeletal; Carbohydrate Metabolism - starch and sucrose

Chromosomal Location of Human Ortholog: 12p12.2

Cellular Component: cortical actin cytoskeleton; cytoskeleton; ectoplasm; cytoplasm; cell cortex; cytosol

Molecular Function: protein homodimerization activity; glycogen (starch) synthase activity

Biological Process: generation of precursor metabolites and energy; glycogen biosynthetic process; carbohydrate metabolic process; response to glucose stimulus; glucose metabolic process; pathogenesis

Disease: Glycogen Storage Disease 0, Liver