Western Blot (WB)
(MXI1 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the MXI1 antibody detected the MXI1 protein (arrow).)
Rabbit MXI1 Polyclonal Antibody | anti-MXI1 antibody
MXI1 Antibody (Center)
Western Blot (WB)
(MXI1 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the MXI1 antibody detected the MXI1 protein (arrow).)
Western Blot (WB)
(MXI1 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the MXI1 antibody detected the MXI1 protein (arrow).)
transcription factor, is tightly regulated in normal cells but is
frequently deregulated in human cancers. The protein encoded by
this gene is a transcriptional repressor thought to negatively
regulate MYC function, and is therefore a potential tumor
suppressor. This protein inhibits the transcriptional activity of
MYC by competing for MAX, another basic helix-loop-helix protein
that binds to MYC and is required for its function. Defects in this
gene are frequently found in patients with prostate tumors. Three
alternatively spliced transcripts encoding different isoforms have
been described. Additional alternatively spliced transcripts may
exist but the products of these transcripts have not been verified
experimentally.
Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)
Tsao, C.C., et al. Cancer Biol. Ther. 7(10):1619-1627(2008)
Suo, X.H., et al. Zhonghua Xue Ye Xue Za Zhi 28(11):745-749(2007)
Dugast-Darzacq, C., et al. FEBS J. 274(17):4643-4653(2007)
NCBI and Uniprot Product Information
NCBI Description
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
Uniprot Description
Mad2: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. Defects in MXI1 may be a cause of susceptibility to prostate cancer (PC). It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Oncoprotein
Chromosomal Location of Human Ortholog: 10q24-q25
Cellular Component: cytoplasm; nucleolus; nucleus
Molecular Function: protein dimerization activity; DNA binding; transcription corepressor activity
Biological Process: negative regulation of cell proliferation; cytoplasmic sequestering of transcription factor; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter
Disease: Prostate Cancer
Research Articles on MXI1
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Product Notes
The MXI1 mxi1 (Catalog #AAA9203588) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 53-82. The MXI1 Antibody (Center) reacts with Mouse (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's MXI1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MXI1 mxi1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MXI1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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