Rabbit anti-Human, Mouse Glycine Receptor, alpha1 Polyclonal Antibody | anti-GLRA1 antibody
Glycine Receptor, alpha1
Affinity Purified
Affinity Purified
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor. The receptor mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Uniprot Description
GLRA1: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Defects in GLRA1 are the cause of hyperekplexia, hereditary, type 1 (HKPX1). A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub- subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: postsynaptic membrane; intracellular membrane-bound organelle; integral to plasma membrane; integral to membrane; plasma membrane; cell junction; external side of plasma membrane
Molecular Function: protein binding; transmitter-gated ion channel activity; extracellular-glycine-gated chloride channel activity; glycine binding; taurine binding
Biological Process: regulation of action potential; startle response; synaptic transmission, glycinergic; righting reflex; acrosome reaction; neurological control of breathing; chloride transport; adult walking behavior; neuromuscular process controlling posture; regulation of inhibitory postsynaptic membrane potential; regulation of membrane potential; negative regulation of transmission of nerve impulse; muscle contraction; visual perception; neuropeptide signaling pathway; ion transport; transmembrane transport
Disease: Hyperekplexia, Hereditary 1
Research Articles on GLRA1
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Product Notes
The GLRA1 glra1 (Catalog #AAA614151) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Glycine Receptor, alpha1 reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Glycine Receptor, alpha1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). Western Blot: 1:10 using ECL Immunoprecipitation: 1:10 following the protocol of Raymond et al, Nature (1993) 361:637-641. Researchers should empirically determine the suitability of the GLRA1 glra1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Glycine Receptor, alpha1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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