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Testing Data (Staining of rat trigeminal motor nucleus using MBS616849)

Glutamate Transporter, Glial Polyclonal Antibody | anti-Slc1a2 antibody

Guinea pig Anti-Glutamate Transporter, Glial

Gene Names
Slc1a2; GLT1; Eaat2; GLT-1; MGLT1; AI159670; 1700091C19Rik; 2900019G14Rik
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunofluorescence
Purity
Serum
Synonyms
Glutamate Transporter; Glial; Polyclonal Antibody; Guinea pig Anti-Glutamate Transporter; SLC1A2; EAAT2; GLT1; Excitatory Amino Acid Transporter 2; Solute Carrier Family 1 Member 2; anti-Slc1a2 antibody
Ordering
For Research Use Only!
Host
Host: Guinea pig; Source: Rat
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes rat Glial Glutamate Transporter GLT-1 (EAAT2). Species Crossreactivity: human and mouse
Purity/Purification
Serum
Form/Format
Supplied as a liquid, 0.05% sodium azide
Applicable Applications for anti-Slc1a2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
Immunohistochemistry (Paraffin): 1:1000-1:4000 Immunohistochemistry: 1:5000-10,000 Western Blot: 1:500 detected GLT-1 on 10ug of mouse brain lysates Optimal dilution to be determined by researcher
Immunogen
Synthetic peptide corresponding to the C-terminal of rat GLT-1
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Testing Data

(Staining of rat trigeminal motor nucleus using MBS616849)

Testing Data (Staining of rat trigeminal motor nucleus using MBS616849)

Testing Data

(Staining of rat striatum using MBS616849.)

Testing Data (Staining of rat striatum using MBS616849.)
Related Product Information for anti-Slc1a2 antibody
Glutamate transporters (GluT) function to remove L-glutamate (Glu), the primary excitatory neurotransmitter in the mammalian central nervous system (CNS), from the synaptic cleft. By clearing the synapse in this manner Glu can be recycled for later use, the proper diffusion gradient can be maintained and excitotoxicity can be prevented. There have been reports of many different members of a GluT multigene family; GLT1, GLAST, EAAC1 and EAAT2. mRNA has been identified in brain for each of these proteins.

EAAT2 transports L-glutamate and also L- and D-aspartate. It is essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
Product Categories/Family for anti-Slc1a2 antibody

NCBI and Uniprot Product Information

NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
62,030 Da
NCBI Official Full Name
glutamate transporter
NCBI Official Synonym Full Names
solute carrier family 1 (glial high affinity glutamate transporter), member 2
NCBI Official Symbol
Slc1a2
NCBI Official Synonym Symbols
GLT1; Eaat2; GLT-1; MGLT1; AI159670; 1700091C19Rik; 2900019G14Rik
NCBI Protein Information
excitatory amino acid transporter 2; OTTMUSP00000015765; OTTMUSP00000015766; OTTMUSP00000015767; OTTMUSP00000015768; solute carrier family 1 member 2; solute carrier family 1, member 2; glial high affinity glutamate transporter; sodium-dependent glutamate/aspartate transporter 2
UniProt Protein Name
Excitatory amino acid transporter 2
UniProt Gene Name
Slc1a2
UniProt Synonym Gene Names
Eaat2; Glt1
UniProt Entry Name
EAA2_MOUSE

Uniprot Description

GLT1: an integral membrane protein belonging to the sodium:dicarboxylate (SDF) symporter family. Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by co-transporting sodium.

Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter

Cellular Component: presynaptic membrane; neuron projection; membrane; integral to plasma membrane; axon; integral to membrane; dendritic spine; plasma membrane; synapse; axolemma; dendritic shaft

Molecular Function: symporter activity; high-affinity glutamate transmembrane transporter activity; glutamate:sodium symporter activity; sodium:dicarboxylate symporter activity; L-glutamate transmembrane transporter activity

Biological Process: response to drug; response to light stimulus; nervous system development; L-glutamate transport; multicellular organism growth; multicellular organismal aging; response to amino acid stimulus; visual behavior; L-glutamate import; positive regulation of glucose import; telencephalon development; dicarboxylic acid transport; transport; adult behavior; cellular response to extracellular stimulus; response to wounding

Research Articles on Slc1a2

Similar Products

Product Notes

The Slc1a2 slc1a2 (Catalog #AAA616849) is an Antibody produced from Host: Guinea pig; Source: Rat and is intended for research purposes only. The product is available for immediate purchase. The Guinea pig Anti-Glutamate Transporter, Glial reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Glutamate Transporter, Glial can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Immunohistochemistry (Paraffin): 1:1000-1:4000 Immunohistochemistry: 1:5000-10,000 Western Blot: 1:500 detected GLT-1 on 10ug of mouse brain lysates Optimal dilution to be determined by researcher. Researchers should empirically determine the suitability of the Slc1a2 slc1a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Glutamate Transporter, Glial, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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