Rabbit GLUCOSE TRANSPORTER 1 Polyclonal Antibody | anti-GLUT-1 antibody
RABBIT ANTI HUMAN GLUT-1
Purified IgG - liquid
Western Blotting: Minimum Dilution: 1; Maximum Dilution: 10ug/ml
Preparation
Buffer Solution
Shelf Life: 18 months from date of despatch.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]
Uniprot Description
GLUT1: an integral membrane protein that plays an important role in the glycolytic pathway by serving as a uniporter for glucose. One of 13 members of the human equilibrative glucose transport protein family. Transports a wide range of aldoses, including both pentoses and hexoses, and dehydroascorbic acid. Shown to transport water against an osmotic gradient. A receptor for the Human T-cell Leukemia virus (HTLV). Plays a role in the constitutive or basal uptake of glucose. Expressed at highest levels in proliferating cells of the early developing embryo, cells forming the blood tissue barriers, in human erythrocytes, astrocytes and in cardiac muscle. GLUT1 and GLUT3 are both essential for normal embryonic development. Is practically the only member of the GLUT family expressed on human red blood cells, where it comprises 10 - 20% of the integral membrane protein content. Several glycolytic proteins including the transporters GLUT1 and GLUT3, as well as multiple enzymes including HK2, PFKL, LDHA, ALDOA, ALDOC, PGK1, ENO1, PKM2, CA9 and PFKFB3 are induced in cancer cells by HIF-1 alpha. Polyps from Peutz-Jeghers patients exhibit up-regulated mTORC1 signaling, HIF-1alpha, and GLUT1 levels. Defects in GLUT1 are the cause of autosomal dominant GLUT1 deficiency syndrome, a blood-brain barrier glucose transport defect characterized by infantile seizures, delayed development, and acquired microcephaly. Defects also cause dystonia type 18, an exercise-induced paroxysmal dystonia/dyskinesia. Cytochalasin B binds to its inner surface, inhibiting its glucose transport activity with an IC50 of 0.44 uM.
Protein type: Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 1p34.2
Cellular Component: cortical actin cytoskeleton; membrane; basolateral plasma membrane; integral to plasma membrane; melanosome; plasma membrane; female pronucleus; midbody; intercellular junction; caveola; cytosol
Molecular Function: xenobiotic transporter activity; identical protein binding; D-glucose transmembrane transporter activity; protein binding; protein self-association; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; kinase binding
Biological Process: vitamin metabolic process; L-ascorbic acid metabolic process; pathogenesis; glucose transport; response to osmotic stress; cellular response to glucose starvation; hexose transport; carbohydrate metabolic process; energy reserve metabolic process; protein complex assembly; xenobiotic transport; regulation of insulin secretion; transmembrane transport; water-soluble vitamin metabolic process
Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 12; Dystonia 9; Glut1 Deficiency Syndrome 1; Glut1 Deficiency Syndrome 2
Research Articles on GLUT-1
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Product Notes
The GLUT-1 slc2a1 (Catalog #AAA222074) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI HUMAN GLUT-1 reacts with Bovine (Expected from Sequence), Cat (Expected from Sequence), Dog (Expected from Sequence), Horse (Expected from Sequence), Mouse, Pig (Expected from Sequence), Rabbit (Expected from Sequence), Rat, Rhesus Monkey (Expected from Sequence), Sheep (Expected and may cross-react with other species as described in the data sheet. AAA Biotech's GLUCOSE TRANSPORTER 1 can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Western Blot (WB). Immunoprecipitation: Minimum Dilution: 1; Maximum Dilution: 10ug/ml; Western Blotting: Minimum Dilution: 1; Maximum Dilution: 10ug/ml. Researchers should empirically determine the suitability of the GLUT-1 slc2a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GLUCOSE TRANSPORTER 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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