Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer using GLRA1 Polyclonal Antibody at dilution of 1/20)
Rabbit GLRA1 Polyclonal Antibody | anti-GLRA1 antibody
GLRA1 Polyclonal Antibody
IHC: 1:10-50
WB: 1:500-2000
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer using GLRA1 Polyclonal Antibody at dilution of 1/20)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer using GLRA1 Polyclonal Antibody at dilution of 1/20)
Western Blot (WB)
(Western Blot analysis of Human placenta tissue using GLRA1 Polyclonal Antibody at dilution of 1/250)
Western Blot (WB)
(Western Blot analysis of Human placenta tissue using GLRA1 Polyclonal Antibody at dilution of 1/250)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found. [provided by RefSeq, Dec 2015]
Uniprot Description
Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol ().
Research Articles on GLRA1
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Product Notes
The GLRA1 glra1 (Catalog #AAA2542730) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GLRA1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GLRA1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). ELISA: 1:2000-5000 IHC: 1:10-50 WB: 1:500-2000. Researchers should empirically determine the suitability of the GLRA1 glra1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GLRA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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