Rabbit GJA3 Polyclonal Antibody | anti-GJA3 antibody

GJA3 polyclonal antibody

Cat. Num. AAA3000659

• Gene Names: GJA3; CX46; CZP3
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Immunofluorescence, ELISA
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: GJA3; Polyclonal Antibody; GJA3 polyclonal antibody; Gap junction alpha-3 protein; Connexin-46; Cx46; anti-GJA3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Connexin 46 Polyclonal Antibody detects endogenous levels of Connexin 46 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applicable Applications for anti-GJA3 antibody: Immunohistochemistry-Paraffin (IHC-P), Immunofluorescence (IF)(paraffin section), ELISA (EIA)
• Application Notes: IHC: 1/100-1/300; ELISA: 1/20,000
• Immunogen: The antiserum was produced against synthesized peptide derived from human GJA3. AA range: 151-200
• Preparation and Storage: Store at 4 degee C for short term. Aliquot and store at -20 degee C long term. Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using GJA3 Antibody. The picture on the right is blocked with the synthesized peptide.)

Related Product Information for anti-GJA3 antibody

Background: gap junction protein alpha 3(GJA3) Homo sapiens. The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010]

NCBI and Uniprot Product Information

• NCBI GI #: 22779877
• NCBI GeneID: 2700
• NCBI Accession #: NP_068773.2
• NCBI GenBank Nucleotide #: NM_021954.3
• UniProt Accession #: Q9Y6H8; Q0VAB7; Q9H537
• Molecular Weight: 47,410 Da
• NCBI Official Full Name: gap junction alpha-3 protein
• NCBI Official Synonym Full Names: gap junction protein, alpha 3, 46kDa
• NCBI Official Symbol: GJA3
• NCBI Official Synonym Symbols: CX46; CZP3
• NCBI Protein Information: gap junction alpha-3 protein; connexin 46; connexin-46
• UniProt Protein Name: Gap junction alpha-3 protein
• Protein Family: Gap junction alpha-3 protein
• UniProt Gene Name: GJA3
• UniProt Synonym Gene Names: Cx46
• UniProt Entry Name: CXA3_HUMAN

NCBI Description

The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010]

Uniprot Description

GJA3: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA3 are the cause of cataract zonular pulverulent cataract type 3 (CZP3). A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. Defects in GJA3 are a cause of cataract autosomal dominant (ADC). Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Belongs to the connexin family. Alpha-type (group II) subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q12.11

Cellular Component: connexon complex; integral to membrane

Molecular Function: gap junction channel activity

Biological Process: cell-cell signaling; visual perception; transport; transmembrane transport

Disease: Cataract 14, Multiple Types