Rabbit anti-Human GEMIN6 Polyclonal Antibody | anti-GEMIN6 antibody

GEMIN6 Polyclonal Antibody

Cat. Num. AAA3009566

• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GEMIN6; Polyclonal Antibody; GEMIN6 Polyclonal Antibody; Gem-associated protein 6; Gemin-6; SIP2; anti-GEMIN6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GEMIN6 polyclonal antibody detects endogenous levels of GEMIN6 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 167

• Applicable Applications for anti-GEMIN6 antibody: Western Blot (WB)
• Application Notes: WB: 1:200-1:500
• Immunogen: Recombinant protein of human GEMIN6
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using GEMIN6 antibody.)

Related Product Information for anti-GEMIN6 antibody

GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).

NCBI and Uniprot Product Information

• NCBI GI #: 41393577
• NCBI GeneID: 79833
• NCBI Accession #: NP_079051.9
• NCBI GenBank Nucleotide #: NP_079051.9
• UniProt Accession #: Q8WXD5
• Molecular Weight: ~ 19kDa
• NCBI Official Full Name: gem-associated protein 6
• NCBI Official Synonym Full Names: gem nuclear organelle associated protein 6
• NCBI Official Symbol: GEMIN6
• NCBI Protein Information: gem-associated protein 6
• UniProt Protein Name: Gem-associated protein 6
• Protein Family: Gem-associated protein
• UniProt Gene Name: GEMIN6
• UniProt Synonym Gene Names: Gemin-6

NCBI Description

GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]

Uniprot Description

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.