Rabbit anti-Human KCNE4 Polyclonal Antibody | anti-KCNE4 antibody

KCNE4, ID (KCNE4, Potassium voltage-gated channel subfamily E member 4, MinK-related peptide 3, Minimum potassium ion channel-related peptide 3, Potassium channel subunit beta MiRP3) (FITC)

Cat. Num. AAA6312393

• Gene Names: KCNE4; MIRP3
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: KCNE4; Polyclonal Antibody; ID (KCNE4; Potassium voltage-gated channel subfamily E member 4; MinK-related peptide 3; Minimum potassium ion channel-related peptide 3; Potassium channel subunit beta MiRP3) (FITC); Potassium channel subunit beta MiRP3; anti-KCNE4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
• Sequence Length: 170

• Applicable Applications for anti-KCNE4 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: KCNE4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-86 amino acids from the Central region of human KCNE4.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(KCNE4 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the KCNE4 antibody detected the KCNE4 protein (arrow).)

Related Product Information for anti-KCNE4 antibody

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus.

Product Categories/Family for anti-KCNE4 antibody

Antibodies; Ion Channel

References

Levy, D.I., et al. J. Physiol. (Lond.) 588 (PT 14), 2657-2668 (2010): Sole, L., et al. J. Cell. Sci. 122 (PT 20), 3738-3748 (2009): Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009). Manderfield, L.J., et al. J. Physiol. (Lond.) 587 (PT 2), 303-314 (2009): Levy, D.I., et al. Am. J. Physiol. Renal Physiol. 295 (2), F380-F387 (2008).

NCBI and Uniprot Product Information

• NCBI GI #: 154448884
• NCBI GeneID: 23704
• NCBI Accession #: NP_542402.2
• NCBI GenBank Nucleotide #: NP_542402.2
• UniProt Accession #: Q8WWG9
• NCBI Official Full Name: potassium voltage-gated channel subfamily E member 4
• NCBI Official Synonym Full Names: potassium voltage-gated channel subfamily E regulatory subunit 4
• NCBI Official Symbol: KCNE4
• NCBI Official Synonym Symbols: MIRP3
• NCBI Protein Information: potassium voltage-gated channel subfamily E member 4
• UniProt Protein Name: Potassium voltage-gated channel subfamily E member 4
• Protein Family: Potassium voltage-gated channel subfamily
• UniProt Gene Name: KCNE4

NCBI Description

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]

Uniprot Description

KCNE4: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current. Belongs to the potassium channel KCNE family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q36.1

Cellular Component: apical plasma membrane; integral component of membrane

Molecular Function: protein binding; voltage-gated potassium channel activity