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Western Blot (WB) (Western blot analysis of GDPD5 in mouse kidney tissue lysate with GDPD5 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.)

Rabbit GDPD5 Polyclonal Antibody | anti-GDPD5 antibody

GDPD5 Antibody

Gene Names
GDPD5; GDE2; PP1665
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
GDPD5 antibody is affinity chromatography purified via peptide column.
Synonyms
GDPD5; Polyclonal Antibody; GDPD5 Antibody; GDE2; PP1665; PP6037; PP9363; UNQ1850/PRO3580; Glycerophosphodiester phosphodiesterase domain-containing protein 5; Glycerophosphodiester phosphodiesterase 2; glycerophosphodiester phosphodiesterase domain containing 5; anti-GDPD5 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
GDPD5 antibody is human, mouse and rat reactive. At least three isoforms of GDPD5 are known to exist.
Purity/Purification
GDPD5 antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
605
Applicable Applications for anti-GDPD5 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
GDPD5 antibody can be used for detection of GDPD5 by Western blot at 1 - 2 mug/ml. Antibody can also be used for Immunohistochemistry at 5 mug/mL. For Immunoflorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
GDPD5 antibody was raised against an 18 amino acid peptide near the amino terminus of human GDPD5.
Buffer
GDPD5 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
GDPD5 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

Western Blot (WB)

(Western blot analysis of GDPD5 in mouse kidney tissue lysate with GDPD5 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.)

Western Blot (WB) (Western blot analysis of GDPD5 in mouse kidney tissue lysate with GDPD5 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.)

Immunohistochemistry (IHC)

(Immunohistochemistry of GDPD5 in human kidney tissue with GDPD5 antibody at 5 μg/mL.)

Immunohistochemistry (IHC) (Immunohistochemistry of GDPD5 in human kidney tissue with GDPD5 antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of GDPD5 in human kidney tissue with GDPD5 antibody at 20 μg/mL.)

Immunofluorescence (IF) (Immunofluorescence of GDPD5 in human kidney tissue with GDPD5 antibody at 20 μg/mL.)
Related Product Information for anti-GDPD5 antibody
The glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) protein, also known as GDE2, is a seven transmembrane, widely expressed protein (1) that is necessary for spinal motor neuron differentiation and retinoid-induced neuronal outgrowth (2,3). Altered choline phospholipid metabolism is a hallmark of cancer, and the elevated expression of GDPD5 correlates with malignant choline phospholipid metabolite profiles in human breast cancer (4).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Predicted: 40; 67 kDa

Observed: 52 kDa
NCBI Official Full Name
glycerophosphodiester phosphodiesterase domain-containing protein 5
NCBI Official Synonym Full Names
glycerophosphodiester phosphodiesterase domain containing 5
NCBI Official Symbol
GDPD5
NCBI Official Synonym Symbols
GDE2; PP1665
NCBI Protein Information
glycerophosphodiester phosphodiesterase domain-containing protein 5; glycerophosphodiester phosphodiesterase 2
UniProt Protein Name
Glycerophosphodiester phosphodiesterase domain-containing protein 5
UniProt Gene Name
GDPD5
UniProt Synonym Gene Names
GDE2
UniProt Entry Name
GDPD5_HUMAN

NCBI Description

Glycerophosphodiester phosphodiesterases (GDPDs; EC 3.1.4.46), such as GDPD5, are involved in glycerol metabolism (Lang et al., 2008 [PubMed 17578682]).[supplied by OMIM, Jan 2010]

Uniprot Description

GDPD5: Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine. Belongs to the glycerophosphoryl diester phosphodiesterase family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; EC 3.1.-.-; Membrane protein, integral; Phosphodiesterase

Chromosomal Location of Human Ortholog: 11q13.4-q13.5

Cellular Component: growth cone; perinuclear region of cytoplasm; integral to membrane; endomembrane system

Molecular Function: glycerophosphodiester phosphodiesterase activity

Biological Process: glycerol metabolic process; negative regulation of Notch signaling pathway; lipid metabolic process; spinal cord motor neuron differentiation; positive regulation of neuron differentiation; regulation of timing of cell differentiation; neurite development; cerebral cortex neuron differentiation

Research Articles on GDPD5

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Product Notes

The GDPD5 gdpd5 (Catalog #AAA153670) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GDPD5 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GDPD5 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). GDPD5 antibody can be used for detection of GDPD5 by Western blot at 1 - 2 mug/ml. Antibody can also be used for Immunohistochemistry at 5 mug/mL. For Immunoflorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the GDPD5 gdpd5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GDPD5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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