Rabbit anti-Human GDA Polyclonal Antibody | anti-GDA antibody

GDA, ID (GDA, KIAA1258, Guanine deaminase, Guanine aminohydrolase, p51-nedasin) (AP)

Cat. Num. AAA6301753

• Gene Names: GDA; GAH; CYPIN; GUANASE; NEDASIN
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: GDA; Polyclonal Antibody; ID (GDA; KIAA1258; Guanine deaminase; Guanine aminohydrolase; p51-nedasin) (AP); p51-nedasin; anti-GDA antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
• Sequence Length: 454

• Applicable Applications for anti-GDA antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: GDA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-193 amino acids from the Central region of human GDA.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(GDA Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the GDA antibody detected the GDA protein (arrow).)

Related Product Information for anti-GDA antibody

The protein encoded by this gene is an enzyme that catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. It is also known as a cytosolic regulator of PSD-95 postsynaptic targeting.

Product Categories/Family for anti-GDA antibody

Antibodies; KIAA; orf

References

Martins-de-Souza, D., et al. J Psychiatr Res 44(16):1176-1189(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Lamesch, P., et al. Genomics 89(3):307-315(2007). Kubo, K., et al. J. Med. Invest. 53 (3-4), 264-270 (2006): Sannomiya, K., et al. J. Med. Invest. 53 (3-4), 246-254 (2006).

NCBI and Uniprot Product Information

• NCBI GI #: 4758426
• NCBI GeneID: 9615
• NCBI Accession #: NP_004284.1
• NCBI GenBank Nucleotide #: NP_004284.1
• UniProt Accession #: Q9Y2T3
• NCBI Official Full Name: guanine deaminase isoform b
• NCBI Official Synonym Full Names: guanine deaminase
• NCBI Official Symbol: GDA
• NCBI Official Synonym Symbols: GAH; CYPIN; GUANASE; NEDASIN
• NCBI Protein Information: guanine deaminase
• UniProt Protein Name: Guanine deaminase
• UniProt Gene Name: GDA
• UniProt Synonym Gene Names: KIAA1258; Guanase; Guanine aminase; GAH
• UniProt Entry Name: GUAD_HUMAN

NCBI Description

This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

GDA: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Belongs to the ATZ/TRZ family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.4.3; Nucleotide Metabolism - purine; Hydrolase

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: intracellular; cytosol

Molecular Function: guanine deaminase activity; zinc ion binding

Biological Process: nervous system development; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine nucleotide catabolic process; guanine catabolic process; purine base metabolic process