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Rabbit anti-Human GCSAM Polyclonal Antibody | anti-GCSAM antibody

GCSAM Antibody, Biotin conjugated

Gene Names
GCSAM; HGAL; GCAT2; GCET2
Reactivity
Human
Applications
ELISA
Purity
>95%, Protein G Purified
Synonyms
GCSAM; Polyclonal Antibody; GCSAM Antibody; Biotin conjugated; Germinal center-associated signaling and motility protein; GAL; GCET2; Germinal center B-cell-expressed transcript 2 protein; Germinal center-associated lymphoma protein; hGAL; anti-GCSAM antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
>95%, Protein G Purified
Sequence Length
180
Applicable Applications for anti-GCSAM antibody
ELISA (EIA)
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Biotin
Immunogen
Recombinant human Germinal center-associated signaling and motility protein
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Related Product Information for anti-GCSAM antibody
Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
19,206 Da
NCBI Official Full Name
germinal center-associated signaling and motility protein isoform 3
NCBI Official Synonym Full Names
germinal center-associated, signaling and motility
NCBI Official Symbol
GCSAM
NCBI Official Synonym Symbols
HGAL; GCAT2; GCET2
NCBI Protein Information
germinal center-associated signaling and motility protein
UniProt Protein Name
Germinal center-associated signaling and motility protein
UniProt Gene Name
GCSAM
UniProt Synonym Gene Names
GAL; GCET2; hGAL
UniProt Entry Name
GCSAM_HUMAN

NCBI Description

This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

GCET2: a protein expressed in normal germinal center B cells, immature B and T cells. Induced by IL4. Its expression strongly predicts survival in diffuse large B-cell lymphoma.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 3q13.2

Cellular Component: cytoplasm; plasma membrane

Molecular Function: actin binding; myosin II binding; protein binding; protein kinase binding

Biological Process: regulation of B cell receptor signaling pathway

Research Articles on GCSAM

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Product Notes

The GCSAM gcsam (Catalog #AAA1492564) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GCSAM Antibody, Biotin conjugated reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GCSAM can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the GCSAM gcsam for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GCSAM, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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