Western Blot (WB)
(GCNT2 Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the GCNT2 antibody detected the GCNT2 protein (arrow).)
Rabbit anti-Human, mouse GCNT2 Polyclonal Antibody | anti-GCNT2 antibody
GCNT2 Antibody (C-term)
Western Blot (WB)
(GCNT2 Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the GCNT2 antibody detected the GCNT2 protein (arrow).)
Western Blot (WB)
(GCNT2 Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the GCNT2 antibody detected the GCNT2 protein (arrow).)
Immunohistochemistry (IHC)
(GCNT2 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GCNT2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(GCNT2 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GCNT2 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
the blood group I antigen. The i and I antigens are distinguished
by linear and branched poly-N-acetyllactosaminoglycans,
respectively. The encoded protein is the I-branching enzyme, a
beta-1,6-N-acetylglucosaminyltransferase responsible for the
conversion of fetal i antigen to adult I antigen in erythrocytes
during embryonic development. Mutations in this gene have been
associated with adult i blood group phenotype. Alternatively
spliced transcript variants encoding different isoforms have been
described.
Wang, L., et al. Biochem. Biophys. Res. Commun. 331(4):958-963(2005)
Pras, E., et al. Invest. Ophthalmol. Vis. Sci. 45(6):1940-1945(2004)
Inaba, N., et al. Blood 101(7):2870-2876(2003)
Yu, L.C., et al. Blood 101(6):2081-2088(2003)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
GCNT2B: Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C. Belongs to the glycosyltransferase 14 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transferase; Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.150
Chromosomal Location of Human Ortholog: 6p24.2
Cellular Component: Golgi membrane; membrane; integral to membrane
Molecular Function: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
Biological Process: glycosaminoglycan biosynthetic process; positive regulation of protein kinase B signaling cascade; positive regulation of heterotypic cell-cell adhesion; transforming growth factor beta receptor signaling pathway; multicellular organismal development; positive regulation of cell proliferation; protein amino acid glycosylation; positive regulation of cell migration
Disease: Blood Group, I System; Cataract 13 With Adult I Phenotype
Research Articles on GCNT2
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Product Notes
The GCNT2 gcnt2 (Catalog #AAA9208976) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 364-391. The GCNT2 Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GCNT2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the GCNT2 gcnt2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GCNT2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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