Western Blot (WB)
(Western BlotPositive WB detected in: NIH/3T3 whole cell lysate, HepG2 whole cell lysate, Rat heart tissueAll lanes: GCM2 antibody at 2ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 57 kDaObserved band size: 50 kDa)
Rabbit anti-Human, Rat GCM2 Polyclonal Antibody | anti-GCM2 antibody
GCM2 Antibody
IHC:1:20-1:200
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Avoid repeated freeze.
Western Blot (WB)
(Western BlotPositive WB detected in: NIH/3T3 whole cell lysate, HepG2 whole cell lysate, Rat heart tissueAll lanes: GCM2 antibody at 2ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 57 kDaObserved band size: 50 kDa)
Western Blot (WB)
(Western BlotPositive WB detected in: NIH/3T3 whole cell lysate, HepG2 whole cell lysate, Rat heart tissueAll lanes: GCM2 antibody at 2ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 57 kDaObserved band size: 50 kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human testis tissue using MBS7048241 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human testis tissue using MBS7048241 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7048241 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7048241 at dilution of 1:100)
NCBI and Uniprot Product Information
NCBI Description
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008]
Uniprot Description
GCM2: Probable transcriptional regulator. Defects in GCM2 are a cause of familial isolated hypoparathyroidism (FIH); also known as autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. An autosomal recessive form of FIH also exists.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6p23
Cellular Component: nucleus
Molecular Function: DNA binding; protein binding; sequence-specific DNA binding
Biological Process: cellular calcium ion homeostasis; cellular phosphate ion homeostasis; gliogenesis; parathyroid gland development
Disease: Hypoparathyroidism, Familial Isolated
Research Articles on GCM2
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Product Notes
The GCM2 gcm2 (Catalog #AAA7048241) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GCM2 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GCM2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). WB:1:500-1:5000 IHC:1:20-1:200. Researchers should empirically determine the suitability of the GCM2 gcm2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GCM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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