Rabbit anti-Human GCAP1 Polyclonal Antibody | anti-GUCA1A antibody
Anti-GCAP1 Antibody, Rabbit Polyclonal
Gene Names
GUCA1A; COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131; dJ139D8.6
Reactivity
Human
Applications
ELISA
Purity
Protein A & Antigen Affinity
Synonyms
GCAP1; Polyclonal Antibody; Anti-GCAP1 Antibody; Rabbit Polyclonal; GCAP1/GUCA1A Antibody; Rabbit PAb; Antigen Affinity Purified; guanylate cyclase activator 1A (retina); Anti-C6orf131 Antibody; Anti-COD3 Antibody; Anti-CORD14 Antibody; Anti-dJ139D8.6 Antibody; Anti-GCAP Antibody; Anti-GUCA Antibody; Anti-GUCA1 Antibody; anti-GUCA1A antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human GCAP1/GUCA1A
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; 0.2um filtered solution in PBS
Applicable Applications for anti-GUCA1A antibody
ELISA (EIA)
Application Notes
ELISA: 1:5000-1:10,000
Immunogen
Recombinant Human GCAP1/GUCA1A protein
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with purified, recombinant Human GCAP1/GUCA1A (rh GCAP1/GUCA1A). GCAP1/GUCA1A specific IgG was purified by Human GCAP1/GUCA1A affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-GUCA1A antibody
GCAP 1 gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messenger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase-activating protein 1 (GCAP 1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP 1 promotes the activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in GCAP 1 gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. GCAP 1 stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in the recovery of the dark state of rod photoreceptors following light exposure.
References
Surguchov A, et al. (1997) The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1). Genomics. 39(3):312-22. Subbaraya I, et al. (1995) Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. J Biol Chem. 269(49):31080-9. Payne AM, et al. (1998) A mutation in guanylate cyclase activator 1A (GCAP 1) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1. Hum Mol Genet. 7(2):273-7.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
22,920 Da
NCBI Official Full Name
guanylyl cyclase-activating protein 1
NCBI Official Synonym Full Names
guanylate cyclase activator 1A (retina)
NCBI Official Symbol
GUCA1A
NCBI Official Synonym Symbols
COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131; dJ139D8.6
NCBI Protein Information
guanylyl cyclase-activating protein 1; GCAP 1; cone dystrophy 3; OTTHUMP00000016397; OTTHUMP00000196466; OTTHUMP00000196468; guanylin 1, retina; guanylate cyclase-activating protein, photoreceptor 1
UniProt Protein Name
Guanylyl cyclase-activating protein 1
Protein Family
UniProt Gene Name
GUCA1A
UniProt Synonym Gene Names
C6orf131; GCAP; GCAP1; GUCA1
UniProt Entry Name
GUC1A_HUMAN
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Product Notes
The GUCA1A guca1a (Catalog #AAA8107409) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GCAP1 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GCAP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). ELISA: 1:5000-1:10,000. Researchers should empirically determine the suitability of the GUCA1A guca1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GCAP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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