Rabbit anti-Human, Mouse GATAD2A Polyclonal Antibody | anti-GATAD2A antibody
GATAD2A Antibody
Gene Names
GATAD2A; p66alpha
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
GATAD2A; Polyclonal Antibody; GATAD2A Antibody; FLJ20085; FLJ21017; GATA zinc finger domain containing 2A; GATA zinc finger domain containing protein 2A; GATA zinc finger domain-containing protein 2A; Hp66 alpha; Hp66alpha; OTTHUMP00000201911; OTTHUMP00000201912; P66 alpha; P66A_HUMAN; p66alpha; Transcriptional repressor p66 alpha; Transcriptional repressor p66-alpha; Transcriptional repressor p66alpha; anti-GATAD2A antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
GATAD2A Antibody detects endogenous levels of GATAD2A.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-GATAD2A antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human GATAD2A.
Conjugation
Unconjugated
Similarity
Both CR1 and CR2 regions are required for speckled nuclear localization.
Subunit Structure
Interacts with MBD2 and MBD3. Interaction with MBD2 is required for the enhancement of MBD2-mediated repression and for targeting to the chromatin. Component of the MeCP1 histone deacetylase complex. Interacts with histone tails, including that of histones H2A, H2B, H3 and H4. This interaction is reduced by histone acetylation. Interacts with ERCC6.
Tissue Specificity
Ubiquitous, both in fetal and adult tissues.
Function
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.
Note
peckled nuclear localization requires both CR1 and CR2 regions.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-GATAD2A antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
68,134 Da
NCBI Official Full Name
Homo sapiens GATA zinc finger domain containing 2A (GATAD2A), transcript variant 2, mRNA
NCBI Official Synonym Full Names
GATA zinc finger domain containing 2A
NCBI Official Symbol
GATAD2A
NCBI Official Synonym Symbols
p66alpha
NCBI Protein Information
transcriptional repressor p66-alpha; GATA zinc finger domain-containing protein 2A
UniProt Protein Name
Transcriptional repressor p66-alpha
Protein Family
UniProt Gene Name
GATAD2A
UniProt Synonym Gene Names
Hp66alpha
UniProt Entry Name
P66A_HUMAN
Uniprot Description
GATAD2A: Transcriptional repressor. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: nucleoplasm; nuclear speck; NuRD complex; nucleus
Molecular Function: protein binding, bridging; protein binding; zinc ion binding; sequence-specific DNA binding; transcription factor activity
Biological Process: blood vessel development; embryonic body morphogenesis; neural fold formation; transcription, DNA-dependent; anterior neuropore closure; in utero embryonic development; DNA methylation; programmed cell death; negative regulation of transcription, DNA-dependent
Research Articles on GATAD2A
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Product Notes
The GATAD2A gatad2a (Catalog #AAA9630077) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GATAD2A Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GATAD2A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the GATAD2A gatad2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GATAD2A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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