Goat GAT1/SLC6A1 Polyclonal Antibody | anti-SLC6A1 antibody
Goat anti-GAT1/SLC6A1 Antibody
Western Blot: Preliminary experiments gave bands at approx 50kDa and 37kDa in Human Brain (Cerebellum) lysates after 2ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 67.1kDa according to NP_003033.3. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
NCBI and Uniprot Product Information
NCBI Description
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]
Uniprot Description
SLC6A1: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: axon; cell surface; integral to membrane; integral to plasma membrane; membrane; neuron projection; plasma membrane
Molecular Function: gamma-aminobutyric acid:sodium symporter activity; metal ion binding; neurotransmitter:sodium symporter activity
Biological Process: gamma-aminobutyric acid import; gamma-aminobutyric acid transport; learning; negative regulation of synaptic transmission, GABAergic; neurotransmitter transport; positive regulation of gamma-aminobutyric acid secretion; protein homooligomerization; response to calcium ion; response to cocaine; response to estradiol stimulus; response to lead ion; response to purine; response to sucrose stimulus; response to toxin; synaptic transmission; transmembrane transport; transport
Disease: Myoclonic-atonic Epilepsy
Research Articles on SLC6A1
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Product Notes
The SLC6A1 slc6a1 (Catalog #AAA423006) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-GAT1/SLC6A1 Antibody reacts with Expected from sequence similarity: Human, Rat, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's GAT1/SLC6A1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 4000. Western Blot: Preliminary experiments gave bands at approx 50kDa and 37kDa in Human Brain (Cerebellum) lysates after 2ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 67.1kDa according to NP_003033.3. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands). Researchers should empirically determine the suitability of the SLC6A1 slc6a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: EQPQAGSSTS KE. It is sometimes possible for the material contained within the vial of "GAT1/SLC6A1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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