Rabbit anti-Human GAS41 Polyclonal Antibody | anti-GAS41 antibody

GAS41, NT (A31) (YEATS Domain-containing Protein 4, Glioma-amplified Sequence-41, Gas41, NuMA Binding Protein 1, NuBI-1, NuBI1, YEATS4, GAS41) (MaxLight 490)

Cat. Num. AAA6477901

• Gene Names: YEATS4; YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: GAS41; Polyclonal Antibody; NT (A31) (YEATS Domain-containing Protein 4; Glioma-amplified Sequence-41; Gas41; NuMA Binding Protein 1; NuBI-1; NuBI1; YEATS4; GAS41) (MaxLight 490); anti-GAS41 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NuBI-1.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-GAS41 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-1:500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the N-terminal region of human NuBI-1 (KLH).
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-NuBI-1 Pab in HepG2 cell line lysate. NuBI-1(arrow) was detected using the purified Pab.)

Product Categories/Family for anti-GAS41 antibody

Antibodies; Cancer Markers

References

1. Cai, Y., et al., J. Biol. Chem. 278(44):42733-42736 (2003). 2. Lauffart, B., et al., Genomics 81(2):192-201 (2003). 3. Zimmermann, K., et al., J. Biol. Chem. 277(21):18626-18631 (2002). 4. Debernardi, S., et al., Blood 99(1):275-281 (2002). 5. Munnia, A., et al., Oncogene 20(35):4853-4863 (2001).

NCBI and Uniprot Product Information

• NCBI GI #: 5729838
• NCBI GeneID: 8089
• NCBI Accession #: NP_006521
• NCBI GenBank Nucleotide #: NM_006530.3
• UniProt Accession #: O95619; Q9NQD0
• Molecular Weight: 28.9 kDa (250aa), confirmed by MALDI-TOF
• NCBI Official Full Name: YEATS domain-containing protein 4 isoform 1
• NCBI Official Synonym Full Names: YEATS domain containing 4
• NCBI Official Symbol: YEATS4
• NCBI Official Synonym Symbols: YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
• NCBI Protein Information: YEATS domain-containing protein 4
• UniProt Protein Name: YEATS domain-containing protein 4
• UniProt Gene Name: YEATS4
• UniProt Synonym Gene Names: GAS41; Gas41; NuBI-1; NuBI1
• UniProt Entry Name: YETS4_HUMAN

NCBI Description

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Uniprot Description

YEATS4: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 12q13-q15

Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear matrix; cytoplasm; nucleolus

Molecular Function: protein C-terminus binding; protein binding; DNA binding; structural constituent of cytoskeleton; transcription factor activity

Biological Process: mitosis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of growth; positive regulation of transcription, DNA-dependent