Rabbit anti-Human GALR3 Polyclonal Antibody | anti-GALR3 antibody

GALR3, CT (GALR3, GALNR3, Galanin receptor type 3) (PE)

Cat. Num. AAA6301213

• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: GALR3; Polyclonal Antibody; CT (GALR3; GALNR3; Galanin receptor type 3) (PE); Galanin receptor type 3; anti-GALR3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-GALR3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: GALR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-307 amino acids from the C-terminal region of human GALR3.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(GALR3 Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the GALR3 antibody detected the GALR3 protein (arrow).)

Related Product Information for anti-GALR3 antibody

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts

Product Categories/Family for anti-GALR3 antibody

Antibodies; Receptors

References

Shimada, M., et al. Hum. Genet. 128(4):433-441(2010). Saus, E., et al. J Psychiatr Res 44(14):971-978(2010). Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009): Belfer, I., et al. Genes Brain Behav. 6(5):473-481(2007). Berger, A., et al. Neuroendocrinology 75(2):130-138(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 4503907
• NCBI GeneID: 8484
• NCBI Accession #: NP_003605.1
• NCBI GenBank Nucleotide #: NM_003614.1
• UniProt Accession #: O60755; Q53YJ4
• Molecular Weight: 39,573 Da
• NCBI Official Full Name: galanin receptor type 3
• NCBI Official Synonym Full Names: galanin receptor 3
• NCBI Official Symbol: GALR3
• NCBI Protein Information: galanin receptor type 3; GAL3-R; GALR-3; galanin receptor, family member 3
• UniProt Protein Name: Galanin receptor type 3
• Protein Family: Galanin receptor
• UniProt Gene Name: GALR3
• UniProt Synonym Gene Names: GALNR3; GAL3-R; GALR-3
• UniProt Entry Name: GALR3_HUMAN

NCBI Description

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]

Uniprot Description

GALR3: Receptor for the hormone galanin. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: peptide hormone binding; galanin receptor activity

Biological Process: synaptic transmission; learning and/or memory; neuropeptide signaling pathway; negative regulation of adenylate cyclase activity; feeding behavior; positive regulation of transcription from RNA polymerase II promoter; G-protein signaling, adenylate cyclase inhibiting pathway