NCBI and Uniprot Product Information
NCBI Description
Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma. [provided by RefSeq, Jul 2008]
Uniprot Description
GAL3ST1: Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). Belongs to the galactose-3-O-sulfotransferase family.
Protein type: Lipid Metabolism - sphingolipid; Membrane protein, integral; EC 2.8.2.11; Transferase
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: Golgi membrane; membrane; integral to plasma membrane
Molecular Function: galactosylceramide sulfotransferase activity; sulfotransferase activity
Biological Process: myelination; galactosylceramide biosynthetic process; protein amino acid N-linked glycosylation; spermatogenesis
Research Articles on GAL3ST1
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Product Notes
The GAL3ST1 gal3st1 (Catalog #AAA9405737) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GAL3ST1 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GAL3ST1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500-1:3000. Researchers should empirically determine the suitability of the GAL3ST1 gal3st1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GAL3ST1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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