Rabbit GAIP Polyclonal Antibody | anti-GAIP antibody

GAIP (Phospho-Ser151) Antibody

Cat. Num. AAA9416691

• Gene Names: RGS19; GAIP; RGSGAIP
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Synonyms: GAIP; Polyclonal Antibody; GAIP (Phospho-Ser151) Antibody; RGS19; GNAI3IP; G alpha interacting protein; G-alpha-interacting protein; RGSGAIP; anti-GAIP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: GAIP (Phospho-Ser151) Antibody detects endogenous levels of GAIP only when phosphorylated at Ser151
• Purity/Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 217

• Applicable Applications for anti-GAIP antibody: Western Blot (WB)
• Application Notes: Western Blot: 1:1000
• Immunogen: A synthesized peptide derived from human GAIP (Phospho-Ser151)
• Immunogen Type: Peptide
• Modification: Phospho-Ser151
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis GAIP (Phospho-Ser151) using UV treated K562 whole cell lysates)

Product Categories/Family for anti-GAIP antibody

Phospho-specific Ab

NCBI and Uniprot Product Information

• NCBI GI #: 86990435
• NCBI GeneID: 10287
• NCBI Accession #: NP_001034556.1
• NCBI GenBank Nucleotide #: NM_001039467.1
• UniProt Accession #: P49795; Q53XN0; Q8TD60; A8K216; E1P5G9
• Molecular Weight: 24,636 Da
• NCBI Official Full Name: regulator of G-protein signaling 19
• NCBI Official Synonym Full Names: regulator of G-protein signaling 19
• NCBI Official Symbol: RGS19
• NCBI Official Synonym Symbols: GAIP; RGSGAIP
• NCBI Protein Information: regulator of G-protein signaling 19
• UniProt Protein Name: Regulator of G-protein signaling 19
• Protein Family: DELLA protein
• UniProt Gene Name: RGS19
• UniProt Synonym Gene Names: GAIP; GNAI3IP; RGS19; GAIP
• UniProt Entry Name: RGS19_HUMAN

NCBI Description

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RGS19: inhibits signal transduction by increasing the GTPase activity of g protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(I)a3 > G(I)a1 > G(O)a >> G(Z)a/G(I)a2. Activity on G(Z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Protein type: GAPs; GAPs, RGS

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: beta-catenin destruction complex; cell cortex; cytoplasmic microtubule; Golgi apparatus; heterotrimeric G-protein complex; membrane; postsynaptic density

Molecular Function: beta-catenin binding; GTPase activator activity; protein binding; protein kinase binding

Biological Process: cell death; cell differentiation; dorsal/ventral axis specification; G-protein coupled receptor protein signaling pathway; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction