Immunofluorescence (IF)
(A tissue section through an adult mouse brain showing GAD-1 (red staining) in basket cells of the hippocampal formation. Green staining is autofluorescence from green fluorescent protein (GFP) expressed in this transgenic mouse. Picture courtesy of Dr. Felix Eckenstein, University of Vermont.)
Chicken GAD67 Polyclonal Antibody | anti-GAD67 antibody
Affinity purified Chicken polyclonal GAD67 antibody
IHC: 1:1000-1:2000
WB: 1:2000-1:5000
Suitable immunocytochemistry (2% paraformaldehyde-fixed tissues or cells)
Immunofluorescence (IF)
(A tissue section through an adult mouse brain showing GAD-1 (red staining) in basket cells of the hippocampal formation. Green staining is autofluorescence from green fluorescent protein (GFP) expressed in this transgenic mouse. Picture courtesy of Dr. Felix Eckenstein, University of Vermont.)
Immunofluorescence (IF)
(A tissue section through an adult mouse brain showing GAD-1 (red staining) in basket cells of the hippocampal formation. Green staining is autofluorescence from green fluorescent protein (GFP) expressed in this transgenic mouse. Picture courtesy of Dr. Felix Eckenstein, University of Vermont.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
Uniprot Description
GAD67: Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - butanoate; EC 4.1.1.15; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: intracellular; plasma membrane
Molecular Function: glutamate decarboxylase activity; protein binding
Biological Process: glutamate catabolic process; glutamate decarboxylation to succinate; neurotransmitter secretion; protein-pyridoxal-5-phosphate linkage; synaptic transmission
Disease: Cerebral Palsy, Spastic Quadriplegic, 1
Research Articles on GAD67
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Product Notes
The GAD67 gad1 (Catalog #AAA5306137) is an Antibody produced from Chicken and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's GAD67 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB). ICC: 1:1000-1:2000 IHC: 1:1000-1:2000 WB: 1:2000-1:5000 Suitable immunocytochemistry (2% paraformaldehyde-fixed tissues or cells). Researchers should empirically determine the suitability of the GAD67 gad1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GAD67, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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