Western Blot (WB)
(Western Blot analysis of Rat brain microsome prep probed withMBS624455. Arrow indicates the GABA Receptor A, alpha1 subunit (51kD).)
Rabbit anti-Rat, Mouse GABA Receptor A, alpha 1 Polyclonal Antibody | anti-GABRA1 antibody
GABA Receptor A, alpha 1 (Gamma-aminobutyric Acid Receptor Type A alpha 1 Subunit, GABRA1) (MaxLight 405)
WB: 1:10,000 detects the GABA Receptor A, alpha1 subunit in 10ug of rat brain microsomal preparation. tissue lysate. Proteins were visualized using an IgG (HRP) donkey anti-rabbit and a chemiluminescence detection system.
IP: 5ul immunoprecipitates the GABA Receptor A, alpha1 subunit in rat brain microsomal preparation RIPA lysate.
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western Blot analysis of Rat brain microsome prep probed withMBS624455. Arrow indicates the GABA Receptor A, alpha1 subunit (51kD).)
Western Blot (WB)
(Western Blot analysis of Rat brain microsome prep probed withMBS624455. Arrow indicates the GABA Receptor A, alpha1 subunit (51kD).)
NCBI and Uniprot Product Information
NCBI Description
subunit of GABAA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain [RGD, Feb 2006]
Uniprot Description
GABRA1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Defects in GABRA1 are the cause of childhood absence epilepsy type 4 (ECA4). A subtype of idiopathic generalized epilepsy characterized by onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures may develop. Absence seizures may either remit or persist into adulthood. Defects in GABRA1 are the cause of juvenile myoclonic epilepsy type 5 (EJM5). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.
Protein type: Transporter; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; Channel, ligand-gated
Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction
Molecular Function: chloride channel activity; protein binding; GABA-A receptor activity; GABA receptor activity; benzodiazepine receptor activity; inhibitory extracellular ligand-gated ion channel activity; drug binding
Biological Process: synaptic transmission, GABAergic; chloride transport; gamma-aminobutyric acid signaling pathway
Research Articles on GABRA1
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Product Notes
The GABRA1 gabra1 (Catalog #AAA6477287) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GABA Receptor A, alpha 1 (Gamma-aminobutyric Acid Receptor Type An alpha 1 Subunit, GABRA1) (MaxLight 405) reacts with Rat, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GABA Receptor A, alpha 1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Immunoprecipitation (IP). IHC-P: 1:500 detects the GABA Receptor A, alpha1 subunit in rat hippocampus tissue. Requires HIER. WB: 1:10,000 detects the GABA Receptor A, alpha1 subunit in 10ug of rat brain microsomal preparation. tissue lysate. Proteins were visualized using an IgG (HRP) donkey anti-rabbit and a chemiluminescence detection system. IP: 5ul immunoprecipitates the GABA Receptor A, alpha1 subunit in rat brain microsomal preparation RIPA lysate. Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the GABRA1 gabra1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GABA Receptor A, alpha 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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