Rabbit anti-Human GAB2 Polyclonal Antibody | anti-GAB2 antibody

Anti-GAB2 Antibody

Cat. Num. AAA820761

• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was purified by immunogen affinity chromatography.
• Synonyms: GAB2; Polyclonal Antibody; Anti-GAB2 Antibody; KIAA0571; GRB2-associated-binding protein 2; GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100; anti-GAB2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of GAB2 protein.
• Purity/Purification: The antibody was purified by immunogen affinity chromatography.
• Form/Format: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
• Sequence Length: 638

• Applicable Applications for anti-GAB2 antibody: Western Blot (WB)
• Application Notes: WB (1/500 - 1/1000)
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GAB2. The exact sequence is proprietary.
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of GAB2 expression in K526 (A), MCF7 (B) whole cell lysates.)

Related Product Information for anti-GAB2 antibody

Rabbit polyclonal antibody to GAB2

NCBI and Uniprot Product Information

• NCBI GI #: 6912460
• NCBI GeneID: 9846
• NCBI Accession #: NP_036428.1
• NCBI GenBank Nucleotide #: NM_012296.3
• UniProt Accession #: Q9UQC2; O60317; A2RRM2; A6NEW9; A7MD36
• Molecular Weight: 69,968 Da
• NCBI Official Full Name: GRB2-associated-binding protein 2 isoform b
• NCBI Official Synonym Full Names: GRB2-associated binding protein 2
• NCBI Official Symbol: GAB2
• NCBI Protein Information: GRB2-associated-binding protein 2; pp100; Grb2-associated binder 2; growth factor receptor bound protein 2-associated protein 2
• UniProt Protein Name: GRB2-associated-binding protein 2
• Protein Family: GRB2-associated-binding protein
• UniProt Gene Name: GAB2
• UniProt Synonym Gene Names: KIAA0571
• UniProt Entry Name: GAB2_HUMAN

NCBI Description

This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Uniprot Description

GAB2: an adaptor protein of the GRB2-associated binding protein family. Plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11q14.1

Cellular Component: cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: integrin-mediated signaling pathway; cell migration; phosphoinositide-mediated signaling; positive regulation of cell proliferation; innate immune response; positive regulation of mast cell degranulation; osteoclast differentiation; transmembrane receptor protein tyrosine kinase signaling pathway