Testing Data
Rabbit GAAP Polyclonal Antibody | anti-GAAP antibody
GAAP Antibody
Gene Names
TMBIM6; BI-1; TEGT; BAXI1
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Affinity purified
Synonyms
GAAP; Polyclonal Antibody; GAAP Antibody; Golgi anti-apoptotic protein; Protein S1R; Transmembrane BAX inhibitor motif-containing protein 4; Z-protein; anti-GAAP antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purified
Form/Format
100 ug (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2
Appearance: Colorless liquid
Appearance: Colorless liquid
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
295
Applicable Applications for anti-GAAP antibody
Western Blot (WB)
Application Notes
Western blot: 1:200
Immunogen
Synthetic peptide at N-terminal
Positive Control
Western blot: Jurkat cell lysate, 3T3 cell lysate
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Shelf Life: 12 months
Testing Data
Testing Data
Related Product Information for anti-GAAP antibody
Polyclonal Antibody to detect GAAP in human, mouse and rat samples
Background: The BI-1 (Bax inhibitor 1) family is evolutionarily conserved as integral membrane proteins containing multiple membrane-spanning domains that are predominantly localized to intracellular membranes. BI-1 family members share multiple motifs and transcriptional factors within the promoter and the coding regions. They represent regulators of cell death pathways and are highly conserved in evolution from plants to insects, amphibians, mammals and pox-viruses. GAAP (Golgi anti-apoptotic protein), also known as TMBIM4 (transmembrane Bax inhibitor motif containing 4), S1R, ZPRO or CGI-119, is a 238 amino acid multi-pass membrane protein that belongs to the BI-1 family. Ubiquitously expressed, GAAP inhibits apoptosis induced by intrinsic and extrinsic apoptotic stimuli.
Background: The BI-1 (Bax inhibitor 1) family is evolutionarily conserved as integral membrane proteins containing multiple membrane-spanning domains that are predominantly localized to intracellular membranes. BI-1 family members share multiple motifs and transcriptional factors within the promoter and the coding regions. They represent regulators of cell death pathways and are highly conserved in evolution from plants to insects, amphibians, mammals and pox-viruses. GAAP (Golgi anti-apoptotic protein), also known as TMBIM4 (transmembrane Bax inhibitor motif containing 4), S1R, ZPRO or CGI-119, is a 238 amino acid multi-pass membrane protein that belongs to the BI-1 family. Ubiquitously expressed, GAAP inhibits apoptosis induced by intrinsic and extrinsic apoptotic stimuli.
Product Categories/Family for anti-GAAP antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
32,711 Da
NCBI Official Full Name
bax inhibitor 1 isoform 2
NCBI Official Synonym Full Names
transmembrane BAX inhibitor motif containing 6
NCBI Official Symbol
TMBIM6
NCBI Official Synonym Symbols
BI-1; TEGT; BAXI1
NCBI Protein Information
bax inhibitor 1
UniProt Protein Name
Bax inhibitor 1
UniProt Gene Name
TMBIM6
UniProt Synonym Gene Names
BI1; TEGT; BI-1
UniProt Entry Name
BI1_HUMAN
Uniprot Description
TMBIM6: Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulate ER calcium homeostasis by acting as a calcium-leak channel. Belongs to the BI1 family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to plasma membrane; nucleus
Molecular Function: enzyme binding
Biological Process: endoplasmic reticulum calcium ion homeostasis; negative regulation of mRNA cleavage; negative regulation of protein binding; response to unfolded protein
Research Articles on GAAP
Similar Products
Product Notes
The GAAP tmbim6 (Catalog #AAA841159) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GAAP Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GAAP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blot: 1:200. Researchers should empirically determine the suitability of the GAAP tmbim6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GAAP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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