Testing Data
Rabbit Furin/PACE Polyclonal Antibody | anti-Furin antibody
Furin / PACE Antibody
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Uniprot Description
FURIN: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. Furin subfamily.
Protein type: Membrane protein, integral; Vesicle; Protease; EC 3.4.21.75; Cell surface
Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum membrane; Golgi cisterna; cell surface; early endosome; integral to membrane; trans-Golgi network; lipid raft; trans-Golgi network transport vesicle membrane; trans-Golgi network transport vesicle; membrane; plasma membrane
Molecular Function: serine-type endopeptidase inhibitor activity; peptidase activity; protein binding; protease binding; hydrolase activity; serine-type peptidase activity; metal ion binding; serine-type endopeptidase activity; endopeptidase activity; nerve growth factor binding; peptide binding
Biological Process: signal peptide processing; peptide hormone processing; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of signal transduction; proteolysis; peptide biosynthetic process; nerve growth factor production; negative regulation of transforming growth factor-beta1 production; cell proliferation; regulation of low-density lipoprotein receptor biosynthetic process; regulation of endopeptidase activity; regulation of protein catabolic process; protein processing; negative regulation of low-density lipoprotein receptor catabolic process; secretion by cell; positive regulation of cell migration
Research Articles on Furin
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Product Notes
The Furin furin (Catalog #AAA841072) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Furin / PACE Antibody reacts with Human, Mouse, Rat, Bovine, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's Furin/PACE can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~95-110 kDa Furin/PACE. A splice variant (~60 kDa) can also be detected. Researchers should empirically determine the suitability of the Furin furin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Furin/PACE, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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