Rabbit anti-Human FUK Polyclonal Antibody | anti-FUK antibody

FUK (Fucokinase, 1110046B12Rik, FLJ39408) APC

Cat. Num. AAA6379022

• Gene Names: FUK; 1110046B12Rik
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FUK; Polyclonal Antibody; FUK (Fucokinase; 1110046B12Rik; FLJ39408) APC; anti-FUK antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FUK.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-FUK antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human FUK, aa1-1084 (NP_659496.2).
• Immunogen Sequence: MEQPKGVDWTVIILTCQYKDSVQVFQRELEVRQKREQIPAGTLLLAVEDPEKRVGSGGATLNALLVAAEHLSARAGFTVVTSDVLHSAWILILHMGRDFPFDDCGRAFTCLPVENPEAPVEALVCNLDCLLDIMTYRLGPGSPPGVWVCSTDMLLSVPANPGISWDSFRGARVIALPGSPAYAQNHGVYLTDPQGLVLDIYYQGTEAEIQRCVRPDGRVPLVSGVVFFSVETAERLLATHVSPPLDACTYLGLDSGARPVQLSLFFDILHCMAENVTREDFLVGRPPELGQGDADVAGYLQSARAQLWRELRDQPLTMAYVSSGSYSYMTSSASEFLLSLTLPGAPGAQIVHSQVEEQQLLAAGSSVVSCLLEGPVQLGPGSVLQHCHLQGPIHIGAGCLVTGLDTAHSKALHGRELRDLVLQGHHTRLHGSPGHAFTLVGRLDSWERQGAGTYLNVPWSEFFKRTGVRAWDLWDPETLPAEYCLPSARLFPVLHPSRELGPQDLLWMLDHQEDGGEALRAWRASWRLSWEQLQPCLDRAATLASRRDLFFRQALHKARHVLEARQDLSLRPLIWAAVREGCPGPLLATLDQVAAGAGDPGVAARALACVADVLGCMAEGRGGLRSGPAANPEWMRPFSYLECGDLAAGVEALAQERDKWLSRPALLVRAARHYEGAGQILIRQAVMSAQHFVSTEQVELPGPGQWVVAECPARVDFSGGWSDTPPLAYELGGAVLGLAVRVDGRRPIGARARRIPEPELWLAVGPRQDEMTVKIVCRCLADLRDYCQPHAPGALLKAAFICAGIVHVHSELQLSEQLLRTFGGGFELHTWSELPHGSGLGTSSILAGTALAALQRAAGRVVGTEALIHAVLHLEQVLTTGGGWQDQVGGLMPGIKVGRSRAQLPLKVEVEEVTVPEGFVQKLNDHLLLVYTGKTRLARNLLQDVLRSWYARLPAVVQNAHSLVRQTEECAEGFRQGSLPLLGQCLTSYWEQKKLMAPGCEPLTVRRMMDVLAPHVHGQSLAGAGGGGFLYLLTKEPQQKEALEAVLAKTEGLGNYSIHLVEVDTQGLSLKLLGTEASTCCPFP
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of FUK expression in transfected 293T cell line by FUK polyclonal antibody. Lane 1: FUK transfected lysate (117.6kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-FUK antibody

Fucokinase belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis.

Product Categories/Family for anti-FUK antibody

Antibodies; Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 63175654
• NCBI GeneID: 197258
• NCBI Accession #: NP_659496.2
• NCBI GenBank Nucleotide #: NM_145059.2
• UniProt Accession #: Q8N0W3; Q5PSM3; Q5XKL6; Q6ZRA0; Q96MT9
• Molecular Weight: 117,623 Da
• NCBI Official Full Name: L-fucose kinase
• NCBI Official Synonym Full Names: fucokinase
• NCBI Official Symbol: FUK
• NCBI Official Synonym Symbols: 1110046B12Rik
• NCBI Protein Information: L-fucose kinase
• UniProt Protein Name: L-fucose kinase
• Protein Family: Fukutin
• UniProt Gene Name: FUK
• UniProt Synonym Gene Names: Fucokinase
• UniProt Entry Name: FUK_HUMAN

NCBI Description

The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]

Uniprot Description

FUK: Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides. Belongs to the GHMP kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.1.52; Kinase, other; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: cytoplasm

Molecular Function: fucokinase activity; ATP binding

Biological Process: phosphorylation