Western Blot (WB)
(Western blot analysis of FSCN1 using Jurkat whole lysates.)
Rabbit anti-Human, Mouse FSCN1 Polyclonal Antibody | anti-FSCN1 antibody
FSCN1 Antibody
Gene Names
FSCN1; HSN; SNL; p55; FAN1
Reactivity
Human, Mouse
Applications
Western Blot, ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Synonyms
FSCN1; Polyclonal Antibody; FSCN1 Antibody; 55 kDa actin bundling protein; 55 kDa actin-bundling protein; Actin bundling protein; actin bundling protein; 55-KD; FAN 1; FAN1; Fascin 1; Fascin actin bundling protein 1; Fascin; Fascin homolog 1 actin bundling protein (Strongylocentrotus purpuratus); Fascin homolog 1; sea urchin; homolog of; 1; Fascin1; FLJ38511; FSCN 1; FSCN1_HUMAN; HSN; p55; Singed (Drosophila) like (sea urchin fascin homolog like); Singed drosophila homolog like; Singed like (fascin homolog sea urchin) (Drosophila); Singed like (fascin homolog sea urchin); Singed like protein; Singed; drosophila; Singed-like protein; SNL; Strongylocentrotus purpuratus; anti-FSCN1 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
FSCN1 antibody detects endogenous levels of total FSCN1
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
493
Applicable Applications for anti-FSCN1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:1000-3000
Immunogen
A synthesized peptide derived from human FSCN1
Subcellular Location
Cytoplasm > Cytoskeleton. Cell Projection > Filopodium. Cell Projection > Invadopodium.
Tissue Specificity
Ubiquitous.
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Dog, Chicken
Similarity
Pig (100%), Bovine (100%), Horse (88%), Sheep (100%), Dog (100%), Chicken (100%)
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of FSCN1 using Jurkat whole lysates.)
Western Blot (WB)
(Western blot analysis of FSCN1 using Jurkat whole lysates.)
Related Product Information for anti-FSCN1 antibody
Function: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
Subunit Structure: Interacts with RUFY3 (via N-terminus); the interaction induces neuron axon development. Associates with beta-catenin (By similarity). Interacts with PLXNB3 (PubMed:21706053).
Post-translational Modifications: Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.
Similarity: Composed of four beta-trefoil domains. Belongs to the fascin family.
Subunit Structure: Interacts with RUFY3 (via N-terminus); the interaction induces neuron axon development. Associates with beta-catenin (By similarity). Interacts with PLXNB3 (PubMed:21706053).
Post-translational Modifications: Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin.
Similarity: Composed of four beta-trefoil domains. Belongs to the fascin family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 54 kDa
Predicted: 55 kDa
Predicted: 55 kDa
NCBI Official Full Name
fascin
NCBI Official Synonym Full Names
fascin actin-bundling protein 1
NCBI Official Symbol
FSCN1
NCBI Official Synonym Symbols
HSN; SNL; p55; FAN1
NCBI Protein Information
fascin
UniProt Protein Name
Fascin
Protein Family
UniProt Gene Name
FSCN1
UniProt Synonym Gene Names
FAN1; HSN; SNL
NCBI Description
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]
Uniprot Description
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration.
Research Articles on FSCN1
Similar Products
Product Notes
The FSCN1 fscn1 (Catalog #AAA9608482) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FSCN1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's FSCN1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:1000-3000. Researchers should empirically determine the suitability of the FSCN1 fscn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FSCN1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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