Rabbit anti-Human FRMD3 Polyclonal Antibody | anti-FRMD3 antibody

FRMD3, ID (FRMD3, EPB41L4O, FERM domain-containing protein 3, Band 4.1-like protein 4O, Ovary type protein 4.1)

Cat. Num. AAA6012907

• Gene Names: FRMD3; 4.1O; P410; EPB41LO; EPB41L4O; RP11-439K3.2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: FRMD3; Polyclonal Antibody; ID (FRMD3; EPB41L4O; FERM domain-containing protein 3; Band 4.1-like protein 4O; Ovary type protein 4.1); Anti -FRMD3; anti-FRMD3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-FRMD3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: FRMD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-279 amino acids from the Central region of human FRMD3.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(FRMD3 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the FRMD3 antibody detected the FRMD3 protein (arrow).)

Related Product Information for anti-FRMD3 antibody

Protein 4.1 of red blood cells, or 4.1R (EPB41; MIM 130500), is a multifunctional protein essential for maintaining erythrocyte shape and membrane mechanical properties. The protein 4.1 family comprises a group of structural proteins that includes, in addition to 4.1R, 4.1G (general type; MIM 603237), 4.1B (brain type; MIM 605331), 4.1N (neuron type; MIM 602879), and 4.1O (ovary type).

Product Categories/Family for anti-FRMD3 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 350276220
• NCBI GeneID: 257019
• NCBI Accession #: NP_001231891.1
• NCBI GenBank Nucleotide #: NM_001244962.1
• UniProt Accession #: A2A2Y4; Q53EP2; Q5JV59; Q5VZA1; Q86WP8; Q8IZ44; Q8N3Y5; Q8N9L2; A8MQB0; B4DN14
• Molecular Weight: 68,772 Da
• NCBI Official Full Name: FERM domain-containing protein 3 isoform 5
• NCBI Official Synonym Full Names: FERM domain containing 3
• NCBI Official Symbol: FRMD3
• NCBI Official Synonym Symbols: 4.1O; P410; EPB41LO; EPB41L4O; RP11-439K3.2
• NCBI Protein Information: FERM domain-containing protein 3; protein 4.1O; ovary type protein 4.1; band 4.1-like protein 4; band 4.1-like protein 4O
• UniProt Protein Name: FERM domain-containing protein 3
• Protein Family: FERM domain-containing protein
• UniProt Gene Name: FRMD3
• UniProt Synonym Gene Names: EPB41L4O; 4.1O
• UniProt Entry Name: FRMD3_HUMAN

NCBI Description

The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

FRMD3: Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q21.32

Cellular Component: extrinsic to membrane; cytoskeleton; cytoplasm; integral to membrane

Molecular Function: cytoskeletal protein binding