Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Human Fragile X Mental Retardation 1 Polyclonal Antibody | anti-FMR1 antibody
Polyclonal Antibody to Fragile X Mental Retardation 1 (FMR1)
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:HumanTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:HumanTissue))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010]
Uniprot Description
FMR1: Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression. RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C). Component of the CYFIP1-EIF4E-FMR1 complex which is composed of CYFIP, EIF4E and FMR1. Interacts with CYFIP1 and CYFIP2. The interaction with brain cytoplasmic RNA 1 (BC1) increases binding affinity for the CYFIP1-EIF4E complex in the brain. Homooligomer. Found in a RNP granule complex with IGF2BP1. Directly interacts with SMN and TDRD3. Interacts with the SMN core complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts with FXR1, FXR2, IGF2BP1, NUFIP1, NUFIP2, MCRS1 and RANBP9. Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells. Belongs to the FMR1 family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; RNA-binding; Translation
Chromosomal Location of Human Ortholog: Xq27.3
Cellular Component: axon; axon terminus; Cajal body; cell junction; cell projection; chromocenter; chromosome; chromosome, centromeric region; cytoplasm; cytosol; dendrite; dendritic spine; extrinsic component of plasma membrane; filopodium tip; growth cone; intracellular ribonucleoprotein complex; membrane; mRNA cap complex; neuron projection; nucleolus; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; polysomal ribosome; polysome; postsynaptic density; postsynaptic membrane; presynaptic membrane; SMN complex; synapse
Molecular Function: chromatin binding; identical protein binding; methylated histone residue binding; microtubule binding; miRNA binding; mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA binding; poly(G) binding; poly(U) binding; protein binding; protein heterodimerization activity; protein homodimerization activity; ribosome binding; RNA binding; RNA strand annealing activity; siRNA binding; translation initiation factor binding; translation repressor activity
Biological Process: cellular response to DNA damage stimulus; glutamate receptor signaling pathway; mRNA processing; mRNA transport; negative regulation of translational initiation; positive regulation of filopodium formation; positive regulation of histone phosphorylation; positive regulation of receptor internalization; positive regulation of translation; regulation of alternative mRNA splicing, via spliceosome; regulation of filopodium formation; regulation of mRNA stability; regulation of neurotransmitter secretion; RNA splicing; RNA-mediated gene silencing; viral process
Disease: Fragile X Mental Retardation Syndrome; Fragile X Tremor/ataxia Syndrome; Premature Ovarian Failure 1
Research Articles on FMR1
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Product Notes
The FMR1 fmr1 (Catalog #AAA2026319) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Fragile X Mental Retardation 1 (FMR1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Fragile X Mental Retardation 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the FMR1 fmr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Fragile X Mental Retardation 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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