Rabbit anti-Human FOXQ1 Polyclonal Antibody | anti-FOXQ1 antibody

FOXQ1 (Forkhead box Q1, FKHRL1, Hepatocyte Nuclear Factor 3 Forkhead, HFH1, Winged Helix/Forkhead Transcription Factor)

Cat. Num. AAA615875

• Gene Names: FOXQ1; HFH1
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: FOXQ1; Polyclonal Antibody; FOXQ1 (Forkhead box Q1; FKHRL1; Hepatocyte Nuclear Factor 3 Forkhead; HFH1; Winged Helix/Forkhead Transcription Factor); Anti -FOXQ1 (Forkhead box Q1; anti-FOXQ1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human FOXQ1.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, sodium azide, before the addition of glycerol to 40%.

• Applicable Applications for anti-FOXQ1 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA Titer: 1:225,000.
• Immunogen: Synthetic peptide, RRPGPHLPYPVE, of human FOXQ1 (KLH). Molecular Weight: 41.52kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-FOXQ1 antibody

Transforming growth factor-beta 2 is a transcriptional target for Akt/protein kinase B via this protein. The Forkhead family of transcription factors is involved in tumorigenesis in rhabdomyosarcoma and acute leukemias (1-3). Within the family, three members (FKHR, AFX and FKHRL1) have sequence similarity to the nematode homologue DAF-16, which has been shown to mediate signaling via a pathway involving IGFR1, PI3K and Akt (4-6). There are three Akt phosphorylation sites in the FKHR proteins: Thr24, Ser256 and Ser319. Phosphorylation of FKHR family members at these sites by Akt promotes cell survival and regulates the cell cycle. Phosphorylation regulates FKHR nuclear translocation and target gene transcription (7,8).

Product Categories/Family for anti-FOXQ1 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 145309320
• NCBI GeneID: 94234
• NCBI Accession #: NP_150285.3
• NCBI GenBank Nucleotide #: NM_033260.3
• UniProt Accession #: Q9C009; Q9NS06
• Molecular Weight: 41,526 Da
• NCBI Official Full Name: forkhead box protein Q1
• NCBI Official Synonym Full Names: forkhead box Q1
• NCBI Official Symbol: FOXQ1
• NCBI Official Synonym Symbols: HFH1
• NCBI Protein Information: forkhead box protein Q1; HFH-1; OTTHUMP00000017774; HNF-3/forkhead-like protein 1; winged helix/forkhead transcription factor; hepatocyte nuclear factor 3 forkhead homolog 1
• UniProt Protein Name: Forkhead box protein Q1
• Protein Family: Forkhead box protein
• UniProt Gene Name: FOXQ1
• UniProt Synonym Gene Names: HFH1
• UniProt Entry Name: FOXQ1_HUMAN

NCBI Description

FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001 [PubMed 11747606]).[supplied by OMIM]

Uniprot Description

FOXQ1: Plays a role in hair follicle differentiation.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; hair follicle morphogenesis