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Western Blot (WB) (Western blot analysis of extracts from NIH/3T3 cells treated with using Serum. Left: Using FOXO3A (Ab-253) antibody.Right: Using the same antibody preincubated with synthesized peptide.)

FOXO3A Polyclonal Antibody | anti-FOXO3A antibody

Anti-FOXO3A Rabbit pAb

Gene Names
FOXO3; FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
Affinity Purified
Synonyms
FOXO3A; Polyclonal Antibody; Anti-FOXO3A Rabbit pAb; AF6q21; AF6q21 protein; DKFZp781A0677; FKHR2; FKHRL 1; FKHRL1; FKHRL1P2; Forkhead (Drosophila) homolog (rhabdomyosarcoma) like 1; Forkhead box O3; Forkhead box O3A; Forkhead box protein O3; Forkhead box protein O3A; Forkhead Drosophila homolog of in rhabdomyosarcoma like 1; Forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma like 1; Forkhead in rhabdomyosarcoma-like 1; FOX O3A; FOXO2; foxo3; FOXO3_HUMAN; MGC12739; MGC31925; anti-FOXO3A antibody
Ordering
For Research Use Only!
Host
Rabbit
Source: Human
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Purified
Form/Format
10mM PBS with 0.02% sodium azide, 50% glycerol.
Sequence Length
673
Applicable Applications for anti-FOXO3A antibody
Western Blot (WB), Immunohistochemistry (IHC)
Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human FOXO3A around the phosphorylation site of serine 253.
Sensitivity
This antibody detects endogenous levels of FOXO3A and does not cross-react with related proteins.
Sequence Similarities
Contains 1 fork-head DNA-binding domain.
Subunit Structure
Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration. Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation. Interacts with PIM1. Interacts with DDIT3/CHOP.
Subcellular Location
Cytoplasm; cytosol. Nucleus. Note: Translocates to the nucleus upon oxidative stress and in the absence of survival factors.

Western Blot (WB)

(Western blot analysis of extracts from NIH/3T3 cells treated with using Serum. Left: Using FOXO3A (Ab-253) antibody.Right: Using the same antibody preincubated with synthesized peptide.)

Western Blot (WB) (Western blot analysis of extracts from NIH/3T3 cells treated with using Serum. Left: Using FOXO3A (Ab-253) antibody.Right: Using the same antibody preincubated with synthesized peptide.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using FOXO3A (Ab-253) antibody.)

Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using FOXO3A (Ab-253) antibody.)
Related Product Information for anti-FOXO3A antibody
Entrez Summary: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
71
NCBI Official Full Name
forkhead box protein O3
NCBI Official Synonym Full Names
forkhead box O3
NCBI Official Symbol
FOXO3
NCBI Official Synonym Symbols
FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
NCBI Protein Information
forkhead box protein O3
UniProt Protein Name
Forkhead box protein O3
UniProt Gene Name
FOXO3

NCBI Description

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Uniprot Description

FOXO3A: a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia.

Protein type: Autophagy; DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: beta-catenin binding; chromatin DNA binding; DNA binding; protein binding; protein kinase binding; sequence-specific DNA binding; transcription factor activity

Biological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of apoptosis; positive regulation of erythrocyte differentiation; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; regulation of translation; tumor necrosis factor-mediated signaling pathway

Research Articles on FOXO3A

Similar Products

Product Notes

The FOXO3A foxo3 (Catalog #AAA477132) is an Antibody produced from Rabbit Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti-FOXO3A Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FOXO3A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the FOXO3A foxo3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FOXO3A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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